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Fig. 3 | Cancer Nanotechnology

Fig. 3

From: Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma

Fig. 3

In vitro hypoxia assay in HepG2 cells using Lipo-MGNs by the Image-iT™ Green Hypoxia Reagent. A FACS analysis showing the fluorescence level of the HepG2 cell line after treatment with the Image-IT probe for the control, hypoxia, and 25, 50, 75, and 100 µg/ml groups. B Quantification of FACS data. C Qualitative fluorescent image of HepG2 cells. The data are presented as the mean ± standard deviation with number of samples (n) = 3. The mean % of fluorescence level showed significant differences between the hypoxia and Lipo-MGN treated groups (25, 50 and 100 µg/ml) as analyzed by the Student’s unpaired t-test. A two-tailed probability value (P) less than 0.05 was considered statistically significant. *indicates P < 0.05, ** indicates P < 0.0001

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