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Fig. 8 | Cancer Nanotechnology

Fig. 8

From: Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma

Fig. 8

In vitro oxygen release study of Lipo-MGNs. A Reaction scheme showing the reactivity of Lipo-MGNs towards H2O2 for the production of oxygen. B RT‒PCR analysis of HIF-1α mRNA expression after Lipo-MGN treatment in the HepG2 cell line. HIF-1α mRNA is degraded by the oxygen released by Lipo-MGN. The data are presented as the mean ± standard deviation with number of samples (n) = 3. The mean fold change mRNA expression showed significant differences between the hypoxia and Lipo-MGN (100 µg/ml) treated group as analyzed by the Student’s unpaired t-test. A two-tailed probability value (p) less than 0.05 was considered statistically significant. *Indicates p < 0.05

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