Articles

Clinical and pathological staging of the cancer at the nanoscale

Clinical staging model at the nanoscale (CSMN) has been performed on adenocarcinoma of the colon from five patients ranging in age from 57 to 76 years based on determining their malignant size, estimating thei...

Authors: Emad Y. Moawad

EILDV-conjugated, etoposide-loaded biodegradable polymeric micelles directing to tumor metastatic cells overexpressing α4β1 integrin

In the present study, poly(ethylene glycol)-b-poly(ε-caprolactone) micelles loaded with etoposide (ETO) were formulated and further conjugated with pentapeptide Glu-Ile-Leu-Asp-Val (EILDV) to target α4β1 integrin...

Authors: Mukesh Ukawala, Tushar Rajyaguru, Kiran Chaudhari, A. S. Manjappa, R. S. R. Murthy and Rajiv Gude

Facile synthesis of biocompatible gold nanoparticles from Vites vinefera and its cellular internalization against HBL-100 cells

The remarkable health benefits of the chemical cocktails occluded within Vites vinefera (grapes) have been broadly used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases i...

Authors: Kanchana Amarnath, Nina Liza Mathew, Jayshree Nellore, Chagam Reddy Venkat Siddarth and Jayanthi Kumar

Biotinylated magnetic nanoparticles for pretargeting: synthesis and characterization study

In this paper, we have proposed a simple method to covalently conjugate biotin to magnetic nanoparticles, which can be targeted to the tumour sites by using pretargeting approach with avidin or streptavidin. M...

Authors: Ram Prakash Chauhan, Gurjaspreet Singh, Sweta Singh, Narmada Bag, Manoj Patra, S. R. Vadera, Anil K. Mishra and Rashi Mathur

Using water-soluble C₆₀ fullerenes in anticancer therapy

Growth experiments of transplanted malignant tumors in the presence of water-soluble C₆₀ fullerenes were performed on groups of mice. It was found that C₆₀ fullerenes efficiently inhibit the growth of transplante...

Authors: S. V. Prylutska, A. P. Burlaka, P. P. Klymenko, I. I. Grynyuk, Yu. I. Prylutskyy, Ch. Schütze and U. Ritter

Radiotherapy and risks of tumor regrowth or inducing second cancer

Considerable research is aimed at determining the mechanism by which tumor cures, or regrows or second cancer develops, to be predictable and controllable. The wide range of doses, from low to very high, estim...

Authors: Emad Y. Moawad

Enhanced photodynamic efficacy and efficient delivery of Rose Bengal using nanostructured poly(amidoamine) dendrimers: potential application in photodynamic therapy of cancer

Photodynamic therapy (PDT) is a promising treatment methodology whereby diseased cells and tissues are destroyed by reactive oxygen species (ROS) by using a combination of light and photosensitizers (PS). The ...

Authors: Krishnamoorthy Karthikeyan, Anish Babu, Sang-Jae Kim, Ramachandran Murugesan and Kadarkaraithangam Jeyasubramanian

Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model

Celecoxib, a selective cyclooxygenase-2 inhibitor, has shown potential anticancerous activity against majority of solid tumors especially on patients with colon cancer. However, associations of serious side ef...

Authors: Venkatesan Perumal, Shubhadeep Banerjee, Shubasis Das, R. K. Sen and Mahitosh Mandal

Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting

In this article, the syntheses and optical properties of core/shell quantum dot (CdSe/ZnS) and their applications are reviewed. Nevertheless, the main focus is to provide an overview on biological applications...

Authors: Ahmad SalmanOgli

Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts

Biofunctionalized gold and silver nanoparticles synthesized using different plant extracts of guava and clove in vitro anti-cancer efficacy against four different cancer cell lines human colorectal adenocarcin...

Authors: Deshpande Raghunandan, Bhat Ravishankar, Ganachari Sharanbasava, D. Bedre Mahesh, Vasanth Harsoor, Manjunath S. Yalagatti, M. Bhagawanraju and A. Venkataraman

Erratum to: Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy

Authors: Moutushy Mitra, Fahima Dilnawaz, Ranjita Misra, Anju Harilal, Rama Shenkar Verma, Sanjeeb K. Sahoo and Subramanian Krishnakumar

Evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in Hep G2 cell line

The present study discusses evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in the Hep G2 cell line. Doxorubicin hydrochloride (DOX) nanoparticle...

Authors: Swati A. Guhagarkar, Sharmila B. Majee, Abdul Samad and Padma V. Devarajan

Dual role of nanoparticles as drug carrier and drug

The conventional chemotherapeutic agents used in the treatment of human malignancies are directed nonspecifically against both malignant and nonmalignant cells, often limiting their efficacy with having seriou...

Authors: Hirak Kumar Patra, Anjan Kr. Dasgupta, Sounik Sarkar, Indranil Biswas and Arnab Chattopadhyay

Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy

To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide-co-glycolide) nanoparticles (NPs) were formulated by single emulsion-solvent evaporation method by changing differe...

Authors: Moutushy Mitra, Fahima Dilnawaz, Ranjita Misra, Anju Harilal, Rama Shenkar Verma, Sanjeeb K. Sahoo and Subramanian Krishnakumar

Preface

Authors: Raghuraman Kannan

Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging

Targeted nanoparticles have the potential to deliver a large drug payload specifically to cancer cells. Targeting requires that a ligand on the nanoparticle surface interact with a specific membrane receptor o...

Authors: Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth Ng, Weiguo Cao, Lili Ding, Zhihong Zhang and Gang Zheng

Evaluation of cytotoxicity and mechanism of apoptosis of doxorubicin using folate-decorated chitosan nanoparticles for targeted delivery to retinoblastoma

Nanoparticles are the new entities that can greatly limit the various side effects of systemic chemotherapy, and that coupled with a targeting moiety enables site-specific delivery of drugs. Folate receptors a...

Authors: Suphiya Parveen and Sanjeeb K. Sahoo

Micro- and nanotechnology approaches for capturing circulating tumor cells

Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate in the bloodstream where they are carried to other organs, leading to seeding of new tumors and metastases. CTC have...

Authors: Balaji Panchapakesan, Robert Caprara, Vanessa Velasco, James Loomis, Ben King, Peng Xu, Tom Burkhead, Palaniappan Sethu, L. Jay Stallons, W. Glenn McGregor, Shesh N. Rai, Goetz Kloecker and Eric Wickstrom

Thermo-optical analysis and selection of the properties of absorbing nanoparticles for laser applications in cancer nanotechnology

Applications of nanoparticles (NPs) as photothermal (PT) and photoacoustic (PA) labels and agents for diagnosis and therapy of cancer and other diseases in laser medicine are fast growing areas of research. Ma...

Authors: Victor K. Pustovalov, L. G. Astafyeva, E. Galanzha and V. P. Zharov

Evaluating the potential of polymer nanoparticles for oral delivery of paclitaxel in drug-resistant cancer

The present study was designed to explore the ability of polymeric nanoparticles to restore drug sensitivity to P-glycoprotein over-expressing cancer cells. A multidrug-resistant cell line 2780 AD and its sens...

Authors: V. Bhardwaj, J. A. Plumb, J. Cassidy and M. N. V. Ravi Kumar

Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting

In this study, we report the preparation, luminescence, and targeting properties of folic acid-CdTe quantum dot conjugates. Water-soluble CdTe quantum dots were synthesized and conjugated with folic acid using...

Authors: Preethi Suriamoorthy, Xing Zhang, Guiyang Hao, Alan G. Joly, Surya Singh, Marius Hossu, Xiankai Sun and Wei Chen

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of im...

Authors: Zhao Sun, Wei Wang, Rui Wang, Jinhong Duan, Yan Hu, Jin Ma, Jiayan Zhou, Sishen Xie, Xin Lu, Zhaohui Zhu, Shuchang Chen, Yuanli Zhao, Haiyan Xu, Chen Wang and Xian-Da Yang

A core-shell nanomaterial with endogenous therapeutic and diagnostic functions

In the present communication, we report the fabrication of a unique core-shell inorganic nanomaterial with potential therapeutic and diagnostic functions. It contains an iron–cobalt (FeCo) core that demonstrat...

Authors: Chitta Ranjan Patra, Ying Jing, Yun-Hao Xu, Resham Bhattacharya, Debabrata Mukhopadhyay, James F. Glockner, Jian-Ping Wang and Priyabrata Mukherjee