Articles

Potential carriers of chemotherapeutic drugs: matrix based nanoparticulate polymeric systems

In this work matrix based nanoparticulate polymer systems have been designed using the diacrylate derivative of the well-known biocompatible polymer, poly(ethylene glycol) (PEG). This has been crosslinked usin...

Authors: Dipti Kakkar Thukral, Shweta Dumoga, Shelly Arora, Krishna Chuttani and Anil K Mishra

Gemcitabine-loaded PLGA-PEG immunonanoparticles for targeted chemotherapy of pancreatic cancer

The aim of the present study was the direct covalent coupling of the epidermal growth factor receptor (EGFR)-specific monoclonal antibody (mAb) to the surface of poly(lactide)-co-glycolide (PLGA)-polyethylene ...

Authors: Sahil Aggarwal, Swati Gupta, Dilrose Pabla and R. S. R. Murthy

Biosynthesis of silver nanoparticles using the extract of Alternanthera sessilis—antiproliferative effect against prostate cancer cells

Green synthesis of silver nanoparticles was carried out using the aqueous extract of Alternanthera sessilis under various experimental conditions. The aqueous extract of Alternanthera sessilis showed significant ...

Authors: M. Jannathul Firdhouse and P. Lalitha

Cisplatin-functionalized silica nanoparticles for cancer chemotherapy

Cisplatin is used to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer including breast. Cisplatin was attached to silic...

Authors: Chandrababu Rejeeth, Tapas C. Nag and Soundarapandian Kannan

Intelligent system design for bionanorobots in drug delivery

A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuz...

Authors: Mark Fletcher, Mohammad Biglarbegian and Suresh Neethirajan

Surface modification of cobalt oxide nanoparticles using phosphonomethyl iminodiacetic acid followed by folic acid: a biocompatible vehicle for targeted anticancer drug delivery

The aim of our study was to prepare multifunctional, biocompatible nanoparticles for site-specific drug delivery. Hydrophilic nanoparticles with surface-adorned amine, carboxyl, or aldehyde groups, to be later...

Authors: Sourav Chattopadhyay, Sandeep Kumar Dash, Totan Ghosh, Debasis Das, Panchanan Pramanik and Somenath Roy

Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel

Pectin, a naturally occurring biopolymer has been found to have increasing applications in the pharmaceutical and biotechnology industry. Sugars with their three-dimensional structures are important for many b...

Authors: Anita K. Verma and A. Kumar

Green synthesis of gold nanoparticles and their anticancer activity

As the nano revolution unfolds, it is imperative to integrate nanoscience and medicine. The secret gleaned from nature have led to the generation of biogenic technologies for the fabrication of advanced nanoma...

Authors: Ravi Geetha, Thirunavukkarasu Ashokkumar, Selvaraj Tamilselvan, Kasivelu Govindaraju, Mohamed Sadiq and Ganesan Singaravelu

Fungus-mediated synthesis of silver nanoparticles and evaluation of antitumor activity

Silver nanoparticles (AgNPs) were biologically synthesized using aqueous extract of Agaricus bisporus fungi. Physicochemical analysis of silver nanoparticles revealed that they are of spherical shape ranged size ...

Authors: S. M. El-Sonbaty

Surface plasmon-enhanced Ag/CuS nanocomposites for cancer treatment

Photothermal therapy (PTT) for cancer treatment is the use of heat between 41 and 45 °C to damage cancer cells. As a new type of transducer agent for PTT of cancer, CuS nanoparticles have several advantages. T...

Authors: Chang Yang, Lun Ma, Xiaoju Zou, Guangya Xiang and Wei Chen

Encapsulation of exemestane in polycaprolactone nanoparticles: optimization, characterization, and release kinetics

This study was aimed at developing a polymeric drug delivery system for a steroidal aromatase inhibitor, exemestane (exe) intended for sustained targeted delivery of drug through intravenous route. Carboxylate...

Authors: Abhinesh Kumar and Krutika Sawant

Antileukemic potential of PEGylated gold nanoparticle conjugated with protein toxin (NKCT1) isolated from Indian cobra (Naja kaouthia) venom

Limited efficacy of current first-line treatment for leukemia calls attention for further development of efficient strategies. Recently, much attention has been given to nanoparticle-based drug delivery system...

Authors: Tanmoy Bhowmik, Partha Pratim Saha, Anjan Dasgupta and Antony Gomes

Enhancement of biophoton emission of prostate cancer cells by Ag nanoparticles

Ultraweak intrinsic bioluminescence of cancer cell is a noninvasive method of assessing bioenergetic status of the investigated cells. This weak biophoton emission generated by prostate cancer cells (PC₃) was mea...

Authors: Marius Hossu, Lun Ma, Xiaoju Zou and Wei Chen

Active targeting of HER2-positive breast cancer cells by Herceptin-functionalized organically modified silica nanoparticles

Normal micelle microemulsion method was utilized for fabrication of organically modified silica (ORMOSIL) nanoparticles. The void and dye-doped nanoparticles were synthesized in nonpolar core of two different ...

Authors: Vahid Shirshahi, Fereshteh Shamsipour, Amir Hassan Zarnani, Javad Verdi and Reza Saber

Nanolipid carrier-based thermoreversible gel for localized delivery of docetaxel to breast cancer

Intratumoral and intralesional administration of anticancer drugs in gels and implantable formulations is gaining much importance on account of its advantage of site-specific delivery with highly dependable fr...

Authors: Tanya Vohra, Inderpreet Kaur, Hemraj Heer and Rayasa Ramachandra Murthy

Size-dependent cellular toxicity and uptake of commercial colloidal gold nanoparticles in DU-145 cells

Urinary tract infection (UTI) is a predominant condition in prostate cancer patients. Escherichia coli ORN178 (EC-178) is the uropathogen that causes recurrent infection by binding specifically to adhesins of pro...

Authors: Pallavi Vedantam, George Huang and T. R. Jeremy Tzeng

Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin

Broad spectrum therapeutic potential of curcumin is usually hampered by its photodegradation and low bioavailability. Present investigation was designed with an objective to develop transferrin-mediated solid ...

Authors: Rohit S. Mulik, Jukka Mönkkönen, Risto O. Juvonen, Kakasaheb R. Mahadik and Anant R. Paradkar

Development of in vitro gene delivery system using ORMOSIL nanoparticle: Analysis of p53 gene expression in cultured breast cancer cell (MCF-7)

This article reports on the application of organically modified silica (ORMOSIL) nanoparticles as an efficient in vitro gene delivery system in the recent years. Based on that prime objective, the present stud...

Authors: Chandrababu Rejeeth, Soundarapandian Kannan and Krishnasamy Muthuchelian

Clinical and pathological staging of the cancer at the nanoscale

Clinical staging model at the nanoscale (CSMN) has been performed on adenocarcinoma of the colon from five patients ranging in age from 57 to 76 years based on determining their malignant size, estimating thei...

Authors: Emad Y. Moawad

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents...

Authors: Mi-Ran Choi, Rizia Bardhan, Katie J. Stanton-Maxey, Sunil Badve, Harikrishna Nakshatri, Keith M. Stantz, Ning Cao, Naomi J. Halas and Susan E. Clare

Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development

The development of smart nanoparticles that can exhibit the anti-cancer activity, introduces better efficacy and lower toxicity for treatment. The present study was aimed to evaluate the anti-cancer activity o...

Authors: S. Chattopadhyay, S. P. Chakraborty, D. Laha, R. Baral, P. Pramanik and S. Roy

PLGA nanoparticles loaded with etoposide and quercetin dihydrate individually: in vitro cell line study to ensure advantage of combination therapy

PLGA nanoparticles, separately loaded with etoposide (ETN) and quercetin dihydrate (QDN), were prepared by adapting the solvent diffusion (nanoprecipitation) technique. The effect of formulation variables such...

Authors: Smita Pimple, Arehalli S. Manjappa, Mukesh Ukawala and R. S. R. Murthy

Aptamer-labeled PLGA nanoparticles for targeting cancer cells

Cancer is one of the leading causes of death in most parts of the world and is a very serious cause of concern particularly in developing countries. In this work, we prepared and evaluated the aptamer-labeled ...

Authors: Athulya Aravind, Saino Hanna Varghese, Srivani Veeranarayanan, Anila Mathew, Yutaka Nagaoka, Seiki Iwai, Takahiro Fukuda, Takashi Hasumura, Yasuhiko Yoshida, Toru Maekawa and D. Sakthi Kumar

EILDV-conjugated, etoposide-loaded biodegradable polymeric micelles directing to tumor metastatic cells overexpressing α4β1 integrin

In the present study, poly(ethylene glycol)-b-poly(ε-caprolactone) micelles loaded with etoposide (ETO) were formulated and further conjugated with pentapeptide Glu-Ile-Leu-Asp-Val (EILDV) to target α4β1 integrin...

Authors: Mukesh Ukawala, Tushar Rajyaguru, Kiran Chaudhari, A. S. Manjappa, R. S. R. Murthy and Rajiv Gude

Facile synthesis of biocompatible gold nanoparticles from Vites vinefera and its cellular internalization against HBL-100 cells

The remarkable health benefits of the chemical cocktails occluded within Vites vinefera (grapes) have been broadly used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases i...

Authors: Kanchana Amarnath, Nina Liza Mathew, Jayshree Nellore, Chagam Reddy Venkat Siddarth and Jayanthi Kumar

Biotinylated magnetic nanoparticles for pretargeting: synthesis and characterization study

In this paper, we have proposed a simple method to covalently conjugate biotin to magnetic nanoparticles, which can be targeted to the tumour sites by using pretargeting approach with avidin or streptavidin. M...

Authors: Ram Prakash Chauhan, Gurjaspreet Singh, Sweta Singh, Narmada Bag, Manoj Patra, S. R. Vadera, Anil K. Mishra and Rashi Mathur

Using water-soluble C₆₀ fullerenes in anticancer therapy

Growth experiments of transplanted malignant tumors in the presence of water-soluble C₆₀ fullerenes were performed on groups of mice. It was found that C₆₀ fullerenes efficiently inhibit the growth of transplante...

Authors: S. V. Prylutska, A. P. Burlaka, P. P. Klymenko, I. I. Grynyuk, Yu. I. Prylutskyy, Ch. Schütze and U. Ritter

Radiotherapy and risks of tumor regrowth or inducing second cancer

Considerable research is aimed at determining the mechanism by which tumor cures, or regrows or second cancer develops, to be predictable and controllable. The wide range of doses, from low to very high, estim...

Authors: Emad Y. Moawad

Enhanced photodynamic efficacy and efficient delivery of Rose Bengal using nanostructured poly(amidoamine) dendrimers: potential application in photodynamic therapy of cancer

Photodynamic therapy (PDT) is a promising treatment methodology whereby diseased cells and tissues are destroyed by reactive oxygen species (ROS) by using a combination of light and photosensitizers (PS). The ...

Authors: Krishnamoorthy Karthikeyan, Anish Babu, Sang-Jae Kim, Ramachandran Murugesan and Kadarkaraithangam Jeyasubramanian

Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model

Celecoxib, a selective cyclooxygenase-2 inhibitor, has shown potential anticancerous activity against majority of solid tumors especially on patients with colon cancer. However, associations of serious side ef...

Authors: Venkatesan Perumal, Shubhadeep Banerjee, Shubasis Das, R. K. Sen and Mahitosh Mandal

Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting

In this article, the syntheses and optical properties of core/shell quantum dot (CdSe/ZnS) and their applications are reviewed. Nevertheless, the main focus is to provide an overview on biological applications...

Authors: Ahmad SalmanOgli

Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts

Biofunctionalized gold and silver nanoparticles synthesized using different plant extracts of guava and clove in vitro anti-cancer efficacy against four different cancer cell lines human colorectal adenocarcin...

Authors: Deshpande Raghunandan, Bhat Ravishankar, Ganachari Sharanbasava, D. Bedre Mahesh, Vasanth Harsoor, Manjunath S. Yalagatti, M. Bhagawanraju and A. Venkataraman

Erratum to: Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy

Authors: Moutushy Mitra, Fahima Dilnawaz, Ranjita Misra, Anju Harilal, Rama Shenkar Verma, Sanjeeb K. Sahoo and Subramanian Krishnakumar

Evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in Hep G2 cell line

The present study discusses evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in the Hep G2 cell line. Doxorubicin hydrochloride (DOX) nanoparticle...

Authors: Swati A. Guhagarkar, Sharmila B. Majee, Abdul Samad and Padma V. Devarajan

Dual role of nanoparticles as drug carrier and drug

The conventional chemotherapeutic agents used in the treatment of human malignancies are directed nonspecifically against both malignant and nonmalignant cells, often limiting their efficacy with having seriou...

Authors: Hirak Kumar Patra, Anjan Kr. Dasgupta, Sounik Sarkar, Indranil Biswas and Arnab Chattopadhyay

Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy

To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide-co-glycolide) nanoparticles (NPs) were formulated by single emulsion-solvent evaporation method by changing differe...

Authors: Moutushy Mitra, Fahima Dilnawaz, Ranjita Misra, Anju Harilal, Rama Shenkar Verma, Sanjeeb K. Sahoo and Subramanian Krishnakumar

Preface

Authors: Raghuraman Kannan

Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging

Targeted nanoparticles have the potential to deliver a large drug payload specifically to cancer cells. Targeting requires that a ligand on the nanoparticle surface interact with a specific membrane receptor o...

Authors: Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth Ng, Weiguo Cao, Lili Ding, Zhihong Zhang and Gang Zheng

Evaluation of cytotoxicity and mechanism of apoptosis of doxorubicin using folate-decorated chitosan nanoparticles for targeted delivery to retinoblastoma

Nanoparticles are the new entities that can greatly limit the various side effects of systemic chemotherapy, and that coupled with a targeting moiety enables site-specific delivery of drugs. Folate receptors a...

Authors: Suphiya Parveen and Sanjeeb K. Sahoo

Micro- and nanotechnology approaches for capturing circulating tumor cells

Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate in the bloodstream where they are carried to other organs, leading to seeding of new tumors and metastases. CTC have...

Authors: Balaji Panchapakesan, Robert Caprara, Vanessa Velasco, James Loomis, Ben King, Peng Xu, Tom Burkhead, Palaniappan Sethu, L. Jay Stallons, W. Glenn McGregor, Shesh N. Rai, Goetz Kloecker and Eric Wickstrom

Thermo-optical analysis and selection of the properties of absorbing nanoparticles for laser applications in cancer nanotechnology

Applications of nanoparticles (NPs) as photothermal (PT) and photoacoustic (PA) labels and agents for diagnosis and therapy of cancer and other diseases in laser medicine are fast growing areas of research. Ma...

Authors: Victor K. Pustovalov, L. G. Astafyeva, E. Galanzha and V. P. Zharov

Evaluating the potential of polymer nanoparticles for oral delivery of paclitaxel in drug-resistant cancer

The present study was designed to explore the ability of polymeric nanoparticles to restore drug sensitivity to P-glycoprotein over-expressing cancer cells. A multidrug-resistant cell line 2780 AD and its sens...

Authors: V. Bhardwaj, J. A. Plumb, J. Cassidy and M. N. V. Ravi Kumar

Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting

In this study, we report the preparation, luminescence, and targeting properties of folic acid-CdTe quantum dot conjugates. Water-soluble CdTe quantum dots were synthesized and conjugated with folic acid using...

Authors: Preethi Suriamoorthy, Xing Zhang, Guiyang Hao, Alan G. Joly, Surya Singh, Marius Hossu, Xiankai Sun and Wei Chen

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of im...

Authors: Zhao Sun, Wei Wang, Rui Wang, Jinhong Duan, Yan Hu, Jin Ma, Jiayan Zhou, Sishen Xie, Xin Lu, Zhaohui Zhu, Shuchang Chen, Yuanli Zhao, Haiyan Xu, Chen Wang and Xian-Da Yang

A core-shell nanomaterial with endogenous therapeutic and diagnostic functions

In the present communication, we report the fabrication of a unique core-shell inorganic nanomaterial with potential therapeutic and diagnostic functions. It contains an iron–cobalt (FeCo) core that demonstrat...

Authors: Chitta Ranjan Patra, Ying Jing, Yun-Hao Xu, Resham Bhattacharya, Debabrata Mukhopadhyay, James F. Glockner, Jian-Ping Wang and Priyabrata Mukherjee