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Table 1 Paclitaxel sensitivity of cell lines A2780 and the drug-resistant derivative 2780AD to paclitaxel and paclitaxel nanoparticles

From: Evaluating the potential of polymer nanoparticles for oral delivery of paclitaxel in drug-resistant cancer

 

IC50 (nM)

A2780

2780 AD

24 h

24 h

72 h

Blank nanoparticles

1,774 ± 129

–

3,175 ± 79

Paclitaxel

2.26 ± 0.91

5,240 ± 637

2,013 ± 73

Paclitaxel nanoparticles

0.30 ± 0.03

1,661 ± 89

903 ± 49

  1. Sensitivity is expressed as the IC50 (mean±SEM of three estimations) defined as the concentration of drug required to reduce the absorbance of the wells to 50% of that of the control untreated cells
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Cancer Nanotechnology

ISSN: 1868-6966

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