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Table 1 Paclitaxel sensitivity of cell lines A2780 and the drug-resistant derivative 2780AD to paclitaxel and paclitaxel nanoparticles

From: Evaluating the potential of polymer nanoparticles for oral delivery of paclitaxel in drug-resistant cancer

  IC50 (nM)
A2780 2780 AD
24 h 24 h 72 h
Blank nanoparticles 1,774 ± 129 3,175 ± 79
Paclitaxel 2.26 ± 0.91 5,240 ± 637 2,013 ± 73
Paclitaxel nanoparticles 0.30 ± 0.03 1,661 ± 89 903 ± 49
  1. Sensitivity is expressed as the IC50 (mean±SEM of three estimations) defined as the concentration of drug required to reduce the absorbance of the wells to 50% of that of the control untreated cells