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  1. In this paper, we step forward in optimizing the efficiency of niosomal systems for carrying curcumin and miR-34a as single-/co-delivery to treat breast cancer. Curcumin, via regulation of p53 protein, affects...

    Authors: Najmeh Alsadat Abtahi, Seyed Morteza Naghib, Fatemeh Haghiralsadat and Mohammadmahdi Akbari Edgahi
    Citation: Cancer Nanotechnology 2022 13:28
  2. Compound K (CK) is the minor ginsenoside present in fermented Panax ginseng extract. Despite the pharmacological efficacy of CK, its industrial use has been restricted due to its low water solubility and poor per...

    Authors: Aditi Mitra Puja, Xingyue Xu, Rongbo Wang, Hoon Kim and Yeon-Ju Kim
    Citation: Cancer Nanotechnology 2022 13:27
  3. The ongoing loss of human life owing to various forms of cancer necessitates the development of a more effective/honorable therapeutic approach. Moreover, finding a novel green-synthesized anti-cancer therapy ...

    Authors: Nouf M. Alyami, Hanadi M. Alyami and Rafa Almeer
    Citation: Cancer Nanotechnology 2022 13:26
  4. To enhance the performance of radiotherapy, emerging nanoparticles that can professionally enhance X-ray irradiation to destruct cancer cells are extremely necessary. Here, we examined the potential of PEG-coa...

    Authors: Mahshid Mohammadian, Soraya Emamgholizadeh Minaei and Amin Shiralizadeh Dezfuli
    Citation: Cancer Nanotechnology 2022 13:25
  5. Photothermal therapy (PTT) has become an attractive approach for cancer treatment due to its merits of minimal invasiveness, location selectivity, and suitability for various cancer types. In PTT, photosensiti...

    Authors: Xinyu Qu, Yixing Chen, Zhuyun Cai, Xinyu Zhao, Hua Zeng, Xiaohao Liu, Shuo Tan, Bingqiang Lu, Rui Gao and Feng Chen
    Citation: Cancer Nanotechnology 2022 13:24
  6. Most ovarian cancers are diagnosed at advanced stages characterized by abdominal dissemination and frequently exhibit chemoresistance. Pyruvate dehydrogenase kinase 2 (PDK2) regulates the switch between glycol...

    Authors: Meng Zhang, Ming Du, Xingling Qi, Yumeng Wang, Guiling Li, Congjian Xu and Xiaoyan Zhang
    Citation: Cancer Nanotechnology 2022 13:23
  7. Multi-drug delivery system based on polymer carrier is emerging for alleviating dose-limiting toxicities of first-line cytotoxic anticancer drugs, such as doxorubicin (DOX) for breast cancer chemotherapy. By c...

    Authors: Zhiyong Li, Jiali Liu, Zheng Sun, Yanli Li, Bin Yu, Feng Zhao, Hongbo Wang and Hui Xu
    Citation: Cancer Nanotechnology 2022 13:21
  8. This research was performed to synthesize nanophytosome-loaded high phenolic fraction (HPF) from Juniperus polycarpos fruit extract and investigate its antiproliferation effects against breast cancer in mice mode...

    Authors: Soheila Moeini, Ehsan Karimi and Ehsan Oskoueian
    Citation: Cancer Nanotechnology 2022 13:20
  9. Targeted delivery of chemotherapeutic drugs to tumour cells is a major challenge for cancer chemotherapy. Recent studies show that tumour cell-derived microparticles can be used as vectors to package chemother...

    Authors: Zhou Jiang, Kai Li, Yongzhong Luo, Bin Chen, Fanfan Meng, Huifang Yi, Lemeng Zhang, Hua Yang, Wenwei Zhou, Tianli Cheng, Huihuang Yi, Qing Yi, Xiaoping Wen, Sheng Hu, Hongyan Liu and Jianhua Chen
    Citation: Cancer Nanotechnology 2022 13:19
  10. Despite the increasing interest in combination therapy for the treatment of cancer, controlled delivery of different therapeutics with high body-clearance efficacy and cancer cell specificity remained a great ...

    Authors: Bei Liu, Xiaoning Liu, Xiangyu Zhang, Xi Wu, Chuanbo Li, Zhaogang Sun and Hongqian Chu
    Citation: Cancer Nanotechnology 2022 13:18
  11. A targeted co-administration system of docetaxel (DTX) and curcumin (CUR) using a PEG-modified RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated nanostructured lipid carrier (P/R-NLC) was constructed to exert synergi...

    Authors: Chang Hyun Kim, Byoung Deok Kim, Tae Hwa Lee, Hyeon Kyun Kim, Min Jeong Lyu, Young In Yoon, Yoon Tae Goo, Myung Joo Kang, Sangkil Lee and Young Wook Choi
    Citation: Cancer Nanotechnology 2022 13:17
  12. Tumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of cancer cell growth. This study is designed to combine the newly synthesized two nanocomposites DDM (HA-FA-2DG@DCA@MgO) and AF (HA-FA-A...

    Authors: Noura M. Thabet, Mohamed K. Abdel-Rafei, Gharieb S. El-Sayyad, Mohamed Abd Elkodous, Adel Shaaban, Yi-Chun Du, Laila Ahmed Rashed and Mostafa A. Askar
    Citation: Cancer Nanotechnology 2022 13:16
  13. Nanoparticles play a crucial role in nanodiagnostics, radiation therapy of cancer, and they are now widely used to effectively deliver drugs to specific sites, targeting whole organs and down to single cells, ...

    Authors: Dmitri V. Alexandrov, Nickolay Korabel, Frederick Currell and Sergei Fedotov
    Citation: Cancer Nanotechnology 2022 13:15
  14. Hepatocellular carcinoma (HCC) is one of the most dangerous cancers in all the world. This study focused on prevention and therapy of hepatocellular carcinoma (HCC) using Moringa oleifera extract combined with vi...

    Authors: Eman M. M. Ebrahem, Galal H. Sayed, Gehan N. A. Gad, Kurls E. Anwer and Adli A. Selim
    Citation: Cancer Nanotechnology 2022 13:14
  15. Helicobacter pylori (H. pylori) eradication plays a crucial role in gastric cancer prevention, but the antimicrobial resistance of H. pylori is obstructing this elimination process. In this study, we developed na...

    Authors: Fansen Meng, Hongjin Tao, Yan Mi, Tianyu Yang, Xuanping Wang, Yuyo Go, Yunjuan Lin and Gangshi Wang
    Citation: Cancer Nanotechnology 2022 13:13
  16. In the current study, folic acid-conjugated PEG-PCL-PEG triblock copolymer were synthesized and loaded with 5-fluorouracil and magnetite nanoparticles (5-FU-SPION-PEG-PCL-PEG-FA) for targeted delivery of drug ...

    Authors: Parvin Sadat Mirzaghavami, Samideh Khoei, Sepideh Khoee and Sakine Shirvalilou
    Citation: Cancer Nanotechnology 2022 13:12
  17. Inherent limitations of single cancer therapy are overcome by multi-therapy modality, which integrates characteristics of each therapeutic modality and material chemistry. The multi-modal method has the potent...

    Authors: Kanglin Liu, Shaoying Yan, Zhengshu Liu, Dan Wang, Qing Yang, Xinyun Jiang, Liuxian Chen and Hua Tang
    Citation: Cancer Nanotechnology 2022 13:11
  18. Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in cancer treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially c...

    Authors: Yuxia Ma, Yi Liu, Ying Zhi, Haibin Wang, Mei Yang, Jieting Niu, Li Zhao and Pengsheng Wang
    Citation: Cancer Nanotechnology 2022 13:10
  19. Recently, biosensors have become popular analytical tools for small analytes due to their high sensitivity and wide analytical range. In the present work, development of a novel biosensing method based on tung...

    Authors: Ramin Pourakbari, Mehdi Yousefi, Balal Khalilzadeh, Mahsa Haddad Irani-nezhad, Alireza Khataee, Leili Aghebati-Maleki, Alireza Soleimanian, Amin Kamrani, Forough Chakari-Khiavi, Rozita Abolhasan, Morteza Motallebnezhad, Farhad Jadidi-Niaragh, Bahman Yousefi, Hossein Samadi Kafil, Mohammad Hojjat-Farsangi and Mohammad-Reza Rashidi
    Citation: Cancer Nanotechnology 2022 13:7
  20. There is growing potential for nanocarrier-based drug delivery in cancer. However, an incomplete understanding of nano–bio interactions and the challenges regarding processing and fabrication in scale-up engin...

    Authors: Mujibur Khan, Md. Mahmudul Hasan, Anne Barnett, Raziye Piranlioglu, Mohammad Rashid, Ahmet Alptekin and Ali Arbab
    Citation: Cancer Nanotechnology 2022 13:6
  21. RNA interference holds tremendous potential in the treatment of malignant tumors. However, efficient and biocompatible delivery methods are needed for systemic delivery of small interfering RNA (siRNA). In thi...

    Authors: Shanrong Shu, Xiaoping Liu, Ming Xu, Yaduan Lin and Ruiman Li
    Citation: Cancer Nanotechnology 2022 13:5
  22. Chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Although sorafenib (SO) is the only chemotherapy drug approved by FDA for treatment of HCC, it is associated with several disadvantages incl...

    Authors: Huan Yue, Luxia Gou, Zhenrong Tang, Yuyang Liu, Shengchun Liu and Hua Tang
    Citation: Cancer Nanotechnology 2022 13:4
  23. Zinc oxide nanoparticles (ZONs) are a type of nanomaterial that has presented anti-cancer properties in breast cancer (BC). However, the function of ABCC9 in BC and its correlation with ZONs are still elusive.

    Authors: Yang Li, Cui Jiang, Xiaoxue Zhang, Zhixuan Liao, Long Chen, Shuang Li, Shunxiong Tang, Zhe Fan and Qiang Zhang
    Citation: Cancer Nanotechnology 2022 13:3
  24. Breast cancer is the most frequently occurring cancer among women. Baicalin has been shown to inhibit breast cancer proliferation, but poor aqueous solubility and unknown mechanism of action limit its applicat...

    Authors: Fengjie Liu, Meng Lan, Baoqi Ren, Lihong Li, Tengteng Zou, Zhaodi Kong, Dongmei Fan, Tiange Cai and Yu Cai
    Citation: Cancer Nanotechnology 2022 13:2
  25. Recent advances from studies of graphene and graphene-based derivatives have highlighted the great potential of these nanomaterials as migrastatic agents with the ability to modulate tumor microenvironments. N...

    Authors: Nazely Diban, Marián Mantecón-Oria, María T. Berciano, Alba Puente-Bedia, María J. Rivero, Ane Urtiaga, Miguel Lafarga and Olga Tapia
    Citation: Cancer Nanotechnology 2022 13:1
  26. The purpose of the present study was to evaluate the efficacy of chemo-magnetic hyperthermia (MH), a combination of alternating magnetic field (AMF) and superparamagnetic nanoparticles (SPIONs) coated with Pol...

    Authors: Saba Jahangiri, Samideh Khoei, Sepideh Khoee, Majid Safa, Sakine Shirvalilou and Vahid Pirhajati Mahabadi
    Citation: Cancer Nanotechnology 2021 12:34
  27. Platinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an...

    Authors: B. Rabindran Jermy, D. Almohazey, W. A. Alamoudi, R. M. Palanivel, Nora AlSudairi, H. Dafalla, A. A. Almofleh, T. M. Alfareed and Vijaya Ravinayagam
    Citation: Cancer Nanotechnology 2021 12:33
  28. Microwave ablation (MWA) has become an alternative treatment for unresectable hepatocellular carcinoma (HCC), but it does not eliminate the risk of recurrence and metastasis after treatment. Recent studies hav...

    Authors: Jian Hu, Wenceng Pei, Zhenyou Jiang and Zihuang Li
    Citation: Cancer Nanotechnology 2021 12:32
  29. In recent years, targeted drug delivery strategies have received special attention from the scientific world due to advantages such as more effective therapy and reduction of side effects. The principle of ope...

    Authors: Gabriela Siemiaszko, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Iwona Misztalewska-Turkowicz, Ewelina Dudź, Sylwia Milewska, Paweł Misiak, Izabela Kurowska, Anna Sadowska, Halina Car and Agnieszka Z. Wilczewska
    Citation: Cancer Nanotechnology 2021 12:31
  30. Self-emulsifying drug delivery systems (SEDDSs) have attracted attention because of their effects on solubility and bioavailability of lipophilic compounds. Herein, a SEDDS loaded with lycopene purified from r...

    Authors: Andreanne G. Vasconcelos, Ana Luisa A. N. Barros, Wanessa F. Cabral, Daniel C. Moreira, Ingrid Gracielle M. da Silva, Amandda É. Silva-Carvalho, Miguel P. de Almeida, Lucas F. F. Albuquerque, Raimunda C. dos Santos, Ana Karolinne S. Brito, Felipe Saldanha-Araújo, Daniel D. R. Arcanjo, Maria do Carmo C. Martins, Tatiana K. dos S. Borges, Sônia N. Báo, Alexandra Plácido…
    Citation: Cancer Nanotechnology 2021 12:30
  31. The problems associated with the poor water solubility of anticancer drugs are one of the most important challenges in achieving effective cancer therapy. The present study was designed to evaluate the effect ...

    Authors: Jundong Wang, Tianhao Li, Chaochi Yue, Sen Zhong, Xiangdong Yang, Jun Li and Yuanzhi Li
    Citation: Cancer Nanotechnology 2021 12:29
  32. Phytochemicals and plant extracts are showing promising anticancer potentials. In the current study, the volatile faction (essential oil) of Nigella sativa seeds was evaluated against some hepatocellular carcinom...

    Authors: Ahmed A. Abd-Rabou and Amr E. Edris
    Citation: Cancer Nanotechnology 2021 12:28
  33. Gold nanoparticles (AuNPs) are considered as promising agents to increase the radiosensitivity of tumor cells. However, the biological mechanisms of radiation enhancement effects of AuNPs are still not well un...

    Authors: Alexander P. Klapproth, Jan Schuemann, Stefan Stangl, Tianwu Xie, Wei Bo Li and Gabriele Multhoff
    Citation: Cancer Nanotechnology 2021 12:27
  34. Theranostic nanomedicines contain a nanovehicle that has fluorescent properties and can be used for diagnostic, therapeutic and prognostic purposes. The transferrin receptor expression is 1000-fold higher in r...

    Authors: Madeeha Shahzad Lodhi, Muhammad Tahir Khan, Saira Aftab, Zahoor Qadir Samra, Heng Wang and Dong Qing Wei
    Citation: Cancer Nanotechnology 2021 12:26
  35. Disulfiram (DS), in the presence of copper (Cu), exhibited potent broad anticancer activity. However, its clinical application is limited due to the poor solubility and stability. Hence, a novel nanocombinatio...

    Authors: Marwa M. Abu‑Serie and Marwa Eltarahony
    Citation: Cancer Nanotechnology 2021 12:25
  36. Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choos...

    Authors: Anna Grebinyk, Svitlana Prylutska, Sergii Grebinyk, Maxim Evstigneev, Iryna Krysiuk, Tetiana Skaterna, Iryna Horak, Yanfang Sun, Liudmyla Drobot, Olga Matyshevska, Yuriy Prylutskyy, Uwe Ritter and Marcus Frohme
    Citation: Cancer Nanotechnology 2021 12:24
  37. The apoptosis (a cascade of biochemical reactions leading to suicide of damaged biological cells) is blocked in the cancer cells because of impossibility of cytochrome c (cytC) go out from the mitochondria. Howev...

    Authors: Svetlana H. Hristova and Alexandar M. Zhivkov
    Citation: Cancer Nanotechnology 2021 12:23
  38. The role of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis and chemoresistance has been increasingly recognized. However, it is necessary to search for more effective strategies t...

    Authors: Tengteng Zou, Meng Lan, Fengjie Liu, Lihong Li, Tiange Cai, Huaqin Tian and Yu Cai
    Citation: Cancer Nanotechnology 2021 12:22
  39. Immune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its pre...

    Authors: Rituparna Chakraborty, Ujjal Bose, Goutam Pawaskar, Satish Rao Bola Sadashiva and Ritu Raval
    Citation: Cancer Nanotechnology 2021 12:21
  40. Cancer is one of the most common incident in the world, with malignant tumors having a death rate of up to 19%. A new method of treating cancer cells effectively with minimal cytotoxicity is needed. In the fie...

    Authors: Naseer Ullah Khan, Jing Lin, Muhammad Rizwan Younas, Xukun Liu and Liming Shen
    Citation: Cancer Nanotechnology 2021 12:20
  41. Combination chemo-photothermal therapy appears to be one of the next generations of cancer treatment. In this study hollow gold nanostars (HGNSs) and gold nanocages (GNCs) were synthesized and stabilized with ...

    Authors: Asrin Pakravan, Mehdi Azizi, Fariborz Rahimi, Farhad Bani, Farideh Mahmoudzadeh, Roya Salehi and Mehrdad Mahkam
    Citation: Cancer Nanotechnology 2021 12:19
  42. In the last decade, graphene oxide-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in the field of biomedicine. Due to the versatile su...

    Authors: Lijun Liu, Qingming Ma, Jie Cao, Yang Gao, Shangcong Han, Yan Liang, Tingting Zhang, Yang Song and Yong Sun
    Citation: Cancer Nanotechnology 2021 12:18
  43. Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) is the only available treatment; however, the frequent r...

    Authors: Fawad Ur Rehman, Mohd Ahmar Rauf, Sajjad Ullah, Sana Shaikh, Aqsa Qambrani, Pir Muhammad and Sumaira Hanif
    Citation: Cancer Nanotechnology 2021 12:17
  44. In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. This knowledge allowed us to design a miR10b-targeted therapeutic consisting of an ant...

    Authors: Mariane Le Fur, Alana Ross, Pamela Pantazopoulos, Nicholas Rotile, Iris Zhou, Peter Caravan, Zdravka Medarova and Byunghee Yoo
    Citation: Cancer Nanotechnology 2021 12:16
  45. Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer ...

    Authors: Farnaz Dabbagh Moghaddam, Iman Akbarzadeh, Ehsan Marzbankia, Mahsa Farid, Leila khaledi, Amir Hossein Reihani, Mehrnoosh Javidfar and Pejman Mortazavi
    Citation: Cancer Nanotechnology 2021 12:14
  46. Brain metastases from non-small cell lung cancer (NSCLC) remain one of the most challenging malignancies. Afatinib (Afa) is an orally administered irreversible ErbB family blocker approved for epidermal growth...

    Authors: Yu-Li Lo, Hua-Ching Lin, Shu-Ting Hong, Chih-Hsien Chang, Chen-Shen Wang and Anya Maan-Yuh Lin
    Citation: Cancer Nanotechnology 2021 12:13

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