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  1. Content type: Research

    Nanocarriers have the potential to improve the therapeutic index of currently available drugs by increasing drug efficacy, lowering drug toxicity and achieving steady-state therapeutic levels of drugs over an ...

    Authors: Natalia Lemos Chaves, Danilo Aquino Amorim, Cláudio Afonso Pinho Lopes, Irina Estrela-Lopis, Julia Böttner, Aparecido Ribeiro de Souza and Sônia Nair Báo

    Citation: Cancer Nanotechnology 2019 10:7

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  2. Content type: Review

    Ion-beam cancer therapy, an alternative to a common radiation therapy with X-rays, has been used clinically around the world since 1990s; the number of proton therapy centers as well as facilities using heavie...

    Authors: Eugene Surdutovich and Andrey V. Solov’yov

    Citation: Cancer Nanotechnology 2019 10:6

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  3. Content type: Research

    Relative biological effectiveness (RBE) is a key quantity for the description of radiobiological effects induced by charged-particle irradiation in the context of ion-beam cancer therapy. Since RBE is a comple...

    Authors: Alexey Verkhovtsev, Eugene Surdutovich and Andrey V. Solov’yov

    Citation: Cancer Nanotechnology 2019 10:4

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  4. Content type: Review

    This article reviews radiation chemistry processes induced by high-linear energy transfer (LET) radiation. The first part gives a short historical introduction and defines the essential concepts of radiation c...

    Authors: Gérard Baldacchino, Emilie Brun, Ibtihel Denden, Sarah Bouhadoun, Raphael Roux, Hicham Khodja and Cécile Sicard-Roselli

    Citation: Cancer Nanotechnology 2019 10:3

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  5. Content type: Research

    Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer which is widely used as a matrix to incorporate therapeutic agents. The anticancer activity of targeted folate-modified docetaxel-...

    Authors: Yuri I. Poltavets, Alexander S. Zhirnik, Vasilisa V. Zavarzina, Yuliya P. Semochkina, Valentina G. Shuvatova, Anna A. Krasheninnikova, Sergey V. Aleshin, Danil O. Dronov, Eugeny A. Vorontsov, Vadim Yu. Balabanyan and Galina A. Posypanova

    Citation: Cancer Nanotechnology 2019 10:2

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  6. Content type: Research

    Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose en...

    Authors: Kyle Bromma, Kristy Rieck, Jayesh Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter Cullis, Jan Schuemann and Devika B. Chithrani

    Citation: Cancer Nanotechnology 2019 10:1

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  7. Content type: Research

    Development of biocompatible multifunctional polymeric drug carriers is crucial in modern pharmaceutics aimed to create “smart” drugs. The high potential of the PEGylated comb-like polymeric nanocarrier (PNC) ...

    Authors: Lesya Kobylinska, Igor Patereha, Natalia Finiuk, Natalia Mitina, Anna Riabtseva, Igor Kotsyumbas, Rostyslav Stoika, Alexander Zaichenko and Sandor G. Vari

    Citation: Cancer Nanotechnology 2018 9:11

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  8. Content type: Research

    A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoa...

    Authors: Jeremy M. C. Brown, Gerard G. Hanna, Nathanael Lampe, Balder Villagomez-Bernabe, James R. Nicol, Jonathan A. Coulter and Fred J. Currell

    Citation: Cancer Nanotechnology 2018 9:9

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  9. Content type: Research

    C60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C60 fullerene used alone or being conjugated with chemotherapeutic agents ...

    Authors: Larysa M. Skivka, Svitlana V. Prylutska, Mariia P. Rudyk, Nataliia M. Khranovska, Ievgeniia V. Opeida, Vasyl V. Hurmach, Yuriy I. Prylutskyy, Leonid F. Sukhodub and Uwe Ritter

    Citation: Cancer Nanotechnology 2018 9:8

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  10. Content type: Research

    Recently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or a vehicle for gene and drug delivery. Considering the suitable properties of these material...

    Authors: Marzieh Salimi, Saeed Sarkar, Reza Saber, Hamid Delavari, Ali Mohammad Alizadeh and Hendrik Thijmen Mulder

    Citation: Cancer Nanotechnology 2018 9:7

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  11. Content type: Research

    Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the p...

    Authors: Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson and Helen O. McCarthy

    Citation: Cancer Nanotechnology 2018 9:5

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  12. Content type: Research

    The combined use of radiation therapy and chemotherapy is commonly being used in cancer treatment. The side effects of the treatment can be further minimized through targeted delivery of anticancer drugs and l...

    Authors: Celina Yang, Kyle Bromma, Caterina Di Ciano-Oliveira, Gaetano Zafarana, Monique van Prooijen and Devika B. Chithrani

    Citation: Cancer Nanotechnology 2018 9:4

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  13. Content type: Research

    Nowadays, viral nanoparticles (VNPs) have attracted a lot of attention, although some are concerned that VNPs may reflect on viral entry of virus into animal or plant cells. In the present study, it aimed to i...

    Authors: Neda Esfandiari, Mohsen Karimi Arzanani and Mina Koohi-Habibi

    Citation: Cancer Nanotechnology 2018 9:1

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  14. Content type: Review

    Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of facto...

    Authors: Eudald Casals, Muriel F. Gusta, Macarena Cobaleda-Siles, Ana Garcia-Sanz and Victor F. Puntes

    Citation: Cancer Nanotechnology 2017 8:7

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  15. Content type: Review

    Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure dru...

    Authors: Zahraa Youssef, Régis Vanderesse, Ludovic Colombeau, Francis Baros, Thibault Roques-Carmes, Céline Frochot, Habibah Wahab, Joumana Toufaily, Tayssir Hamieh, Samir Acherar and Amirah Mohd Gazzali

    Citation: Cancer Nanotechnology 2017 8:6

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  16. Content type: Review

    Early diagnosis, monitoring and treatment selection of cancer represent major challenges in medicine. The definition of the complex clinical and molecular landscape of cancer requires the combination of multip...

    Authors: Luca Guerrini, Nicolas Pazos-Perez, Eduardo Garcia-Rico and Ramon Alvarez-Puebla

    Citation: Cancer Nanotechnology 2017 8:5

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  17. Content type: Research

    Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on the enrichment of tumours with nanoparticles to amplify radiation effects ...

    Authors: Sha Li, Erika Porcel, Hynd Remita, Sergio Marco, Matthieu Réfrégiers, Murielle Dutertre, Fabrice Confalonieri and Sandrine Lacombe

    Citation: Cancer Nanotechnology 2017 8:4

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  18. Content type: Review

    Over the past two decades, there has been a significant evolution in the technologies and techniques employed within the radiation oncology environment. Over the same period, extensive research into the use of...

    Authors: Raymond B. King, Stephen J. McMahon, Wendy B. Hyland, Suneil Jain, Karl T. Butterworth, Kevin M. Prise, Alan R. Hounsell and Conor K. McGarry

    Citation: Cancer Nanotechnology 2017 8:3

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  19. Content type: Review

    There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties...

    Authors: Soraia Rosa, Chris Connolly, Giuseppe Schettino, Karl T. Butterworth and Kevin M. Prise

    Citation: Cancer Nanotechnology 2017 8:2

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  20. Content type: Review

    Radiotherapy has been an integral treatment modality for cancer. The field arose from and progressed through innovations in physics, engineering, and biology. The evolution of radiation oncology will rely on t...

    Authors: Yu Mi, Zhiying Shao, Johnny Vang, Orit Kaidar-Person and Andrew Z. Wang

    Citation: Cancer Nanotechnology 2016 7:11

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  21. Content type: Research

    Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatme...

    Authors: Harry W. Clifford, Amy P. Cassidy, Courtney Vaughn, Evaline S. Tsai, Bianka Seres, Nirmesh Patel, Hannah L. O’Neill, Emil Hewage and John W. Cassidy

    Citation: Cancer Nanotechnology 2016 7:10

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  22. Content type: Review

    Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can advers...

    Authors: Kaspar Haume, Soraia Rosa, Sophie Grellet, Małgorzata A. Śmiałek, Karl T. Butterworth, Andrey V. Solov’yov, Kevin M. Prise, Jon Golding and Nigel J. Mason

    Citation: Cancer Nanotechnology 2016 7:8

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  23. Content type: Methodology

    Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987–989, 2001) have prompted the investigati...

    Authors: Norman A. Lapin, Martyna Krzykawska-Serda, Matthew J. Ware, Steven A. Curley and Stuart J. Corr

    Citation: Cancer Nanotechnology 2016 7:5

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  24. Content type: Research

    Despite being one of the most common cancers, bladder cancer is largely inefficiently and inaccurately staged and monitored. Current imaging methods detect cancer only when it has reached “visible” size and ha...

    Authors: Sean K Sweeney, Yi Luo, Michael A O’Donnell and Jose Assouline

    Citation: Cancer Nanotechnology 2016 7:3

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  25. Content type: Research

    Functionalized gold nanoparticles are emerging as a promising nanocarrier for target specific delivery of the therapeutic molecules in a cancer cell, as a result it targeted selectively to the cancer cell and ...

    Authors: Sushma Kalmodia, Suryanarayanan Vandhana, B. R. Tejaswini Rama, Balasubramanyam Jayashree, T. Sreenivasan Seethalakshmi, Vetrivel Umashankar, Wenrong Yang, Colin J. Barrow, Subramanian Krishnakumar and Sailaja V. Elchuri

    Citation: Cancer Nanotechnology 2016 7:1

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  26. Content type: Research

    AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the...

    Authors: Alexandre Detappe, Sijumon Kunjachan, Joerg Rottmann, James Robar, Panagiotis Tsiamas, Houari Korideck, Olivier Tillement and Ross Berbeco

    Citation: Cancer Nanotechnology 2015 6:4

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  27. Content type: Research

    Five year survival for metastatic melanoma (MM) is very low at <10%. Therapeutic options have been limited secondary to systemic toxicity. As a result there has been a growing movement towards developing targe...

    Authors: Sameer Kaiser, Maximilian B MacPherson, Ted A James, Albert Emery, Page Spiess, Albert van der Vliet, Christopher C Landry and Arti Shukla

    Citation: Cancer Nanotechnology 2015 6:1

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  28. Content type: Research

    Encapsulation of drugs in nanoparticles can enhance the accumulation of drugs in tumours, reduce toxicity toward healthy tissue, and improve pharmacokinetics compared to administration of free drug. To achieve...

    Authors: Sofie Snipstad, Sara Westrøm, Yrr Mørch, Mercy Afadzi, Andreas KO Åslund and Catharina de Lange Davies

    Citation: Cancer Nanotechnology 2014 5:8

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    The Erratum to this article has been published in Cancer Nanotechnology 2015 6:3

  29. Content type: Research

    Recently, the addition of nanoparticles (NPs) has been proposed as a new strategy to enhance the effect of radiotherapy particularly in the treatment of aggressive tumors such as glioblastoma. The physical pro...

    Authors: Lenka Štefančíková, Erika Porcel, Pierre Eustache, Sha Li, Daniela Salado, Sergio Marco, Jean-Luc Guerquin-Kern, Matthieu Réfrégiers, Olivier Tillement, François Lux and Sandrine Lacombe

    Citation: Cancer Nanotechnology 2014 5:6

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  30. Content type: Research

    Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted c...

    Authors: Laura E Taggart, Stephen J McMahon, Fred J Currell, Kevin M Prise and Karl T Butterworth

    Citation: Cancer Nanotechnology 2014 5:5

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  31. Content type: Research

    AGuIX nanoparticles are formed of a polysiloxane network surrounded by gadolinium chelates. They present several characteristics. They are easy to produce, they present very small hydrodynamic diameters (<5 nm...

    Authors: Géraldine Le Duc, Stéphane Roux, Amandine Paruta-Tuarez, Sandrine Dufort, Elke Brauer, Arthur Marais, Charles Truillet, Lucie Sancey, Pascal Perriat, François Lux and Olivier Tillement

    Citation: Cancer Nanotechnology 2014 5:4

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  32. Content type: Research

    The possibility of developing novel contrast imaging agents for cancer cellular labelling and fluorescence imaging applications were explored using silica-coated cadmium selenide (CdSe) quantum dots (QDs). The...

    Authors: Muthunayagam Vibin, Ramachandran Vinayakan, Annie John, Francis Boniface Fernandez and Annie Abraham

    Citation: Cancer Nanotechnology 2014 5:1

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