Fig. 5

Effect of PBS (control), free celecoxib, empty liposomes, and liposomal celecoxib on DMBA-induced rat tumor model. Body weight loss of treated groups compared with control (n = 6) (a). Decrease in tumor volume (cubic millimeters) after 30 days of treatment (tumor induction 90 days + treatment 30 days = 120 days) (b). The images of dissected tumor before and after 30 days post-treatment (c). The images of the tumors in rat model were shown (d). The results were presented as mean±SD (n = 3). ***P < 0.001; **P < 0.05, when compared with control group. All images were taken under the identical instrumental conditions and presented at the same intensity scale