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Table 2 Inhibitory concentrations (50%) of various formulations at different times of incubation with B16F10 cells

From: EILDV-conjugated, etoposide-loaded biodegradable polymeric micelles directing to tumor metastatic cells overexpressing α4β1 integrin

Formulation code

IC50 (μM)

24 h

48 h

72 h

ETO

0.087 ± 0.010

0.050 ± 0.004

0.043 ± 0.003

MPCL235

4.3 ± 0.61***

0.082 ± 0.011*

0.034 ± 0.008

EPCL235

2.5 ± 0.30**

0.055 ± 0.007

0.025 ± 0.001**

MPCL570

5.0 ± 0.80***

0.120 ± 0.013***

0.040 ± 0.005

EPCL570

3.1 ± 0.42***

0.075 ± 0.07

0.031 ± 0.002

  1. Values are the mean ± SD (n = 6)
  2. ***P < 0.001, **P < 0.01, *P < 0.05 (compared with ETO at each time point)
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Cancer Nanotechnology

ISSN: 1868-6966

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