Fig. 3

Radiation dose enhancement studies. Clonogenic assays of Panc1 tumor cells post-AGuIX incubation (1 h). a Schematic view of the irradiation setup for the preclinical beam (220 kVp) and b for the clinical beam (6 MV). The flattening filter is removed for the FFF irradiations. c Schematic representation of the clonogenic assay for the preclinical irradiations. Clinical irradiations were performed with the “washing (-)” situation. Blue circles represents the cells. Yellow circles represent the nanoparticles. d Preclinical irradiation setup (SARRP) was used to induce radiation enhancement effect in AGuIX using a 220 kVp beam (left) and clinical irradiation setup (6 MV beam) was used to treat cells with (STD) and without (FFF) flattening filter (right). Linear quadratic models were fitted to experimental data