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Table 6 Correlation between lncRNA expression and apoptosis parameters

From: Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

  HDF-GAS5 HDF-MALAT1 HDF-p53 HDF-p27 HDF-BAX HDF-BCL2 HDF-CASP3 MDA-GAS5 MDA-MALAT1 MDA-p53 MDA-p27 MDA-BAX MDA-BCL2 MDA-CASP3
HDF-GAS5 Correlation coefficient 1.000 − 0.410 0.384 − 0.373 0.980 0.994 − 0.550 − 0.186 0.228 − 0.016 − 0.534 0.676 0.272 − 0.072
Significance (2-tailed) 0.000 0.731 0.749 0.756 0.126 0.072 0.630 0.881 0.854 0.990 0.642 0.527 0.825 0.954
HDF-MALAT1 Correlation coefficient − 0.410 1.000 0.685 0.999 − 0.582 − 0.510 0.987 0.972 0.794 0.918 0.990 − 0.949 0.766 0.939
Significance (2-tailed) 0.731 0.000 0.520 0.025 0.605 0.659 0.101 0.150 0.415 0.259 0.089 0.204 0.444 0.223
HDF-p53 Correlation coefficient 0.384 0.685 1.000 0.714 0.194 0.278 0.561 0.836 0.987 0.917 0.576 − 0.421 0.993 0.894
Significance (2-tailed) 0.749 0.520 0.000 0.494 0.876 0.821 0.621 0.370 0.104 0.261 0.609 0.723 0.075 0.296
HDF-p27 Correlation coefficient − 0.373 0.999 0.714 1.000 − 0.549 − 0.475 0.980 0.981 0.818 0.933 0.984 − 0.936 0.791 0.952
Significance (2-tailed) 0.756 0.025* 0.494 0.000 0.630 0.685 0.127 0.124 0.390 0.234 0.115 0.229 0.419 0.198
HDF-BAX Correlation coefficient 0.980 − 0.582 0.194 − 0.549 1.000 0.996 − 0.703 − 0.376 0.032 − 0.212 − 0.690 0.808 0.077 − 0.267
Significance (2-tailed) 0.126 0.605 0.876 0.630 0.000 0.055* 0.503 0.755 0.980 0.864 0.515 0.401 0.951 0.828
HDF-BCL2 Correlation coefficient 0.994 − 0.510 0.278 − 0.475 0.996 1.000 − 0.640 − 0.295 0.117 − 0.128 − 0.625 0.755 0.162 − 0.183
Significance (2-tailed) 0.072 0.659 0.821 0.685 0.055 0.000 0.558 0.809 0.925 0.918 0.570 0.456 0.896 0.883
HDF-CASP3 Correlation coefficient − 0.550 0.987 0.561 0.980 − 0.703 − 0.640 1.000 0.923 0.688 0.844 1.000 − 0.987 0.655 0.873
Significance (2-tailed) 0.630 0.101 0.621 0.127 0.503 0.558 0.000 0.251 0.517 0.360 0.012* 0.102 0.546 0.325
MDA-GAS5 Correlation coefficient − 0.186 0.972 0.836 0.981 − 0.376 − 0.295 0.923 1.000 0.914 0.985 0.930 − 0.850 0.895 0.993
Significance (2-tailed) 0.881 0.150 0.370 0.124 0.755 0.809 0.251 0.000 0.266 0.109 0.239 0.354 0.294 0.073
MDA-MALAT1 Correlation coefficient 0.228 0.794 0.987 0.818 0.032 0.117 0.688 0.914 1.000 0.970 0.702 − 0.563 0.999 0.955
Significance (2-tailed) 0.854 0.415 0.104 0.390 0.980 0.925 0.517 0.266 0.000 0.156 0.505 0.619 0.029* 0.192
MDA-p53 Correlation coefficient − 0.016 0.918 0.917 0.933 − 0.212 − 0.128 0.844 0.985 0.970 1.000 0.854 − 0.747 0.958 0.998
Significance (2-tailed) 0.990 0.259 0.261 0.234 0.864 0.918 0.360 0.109 0.156 0.000 0.348 0.463 0.185 0.036*
MDA-p27 Correlation coefficient − 0.534 0.990 0.576 0.984 − 0.690 − 0.625 1.000 0.930 0.702 0.854 1.000 − 0.984 0.669 0.882
Significance (2-tailed) 0.642 0.089 0.609 0.115 0.515 0.570 0.012* 0.239 0.505 0.348 0.000 0.114 0.534 0.313
MDA-BAX Correlation coefficient 0.676 − 0.949 − 0.421 − 0.936 0.808 0.755 − 0.987 − 0.850 − 0.563 − 0.747 − 0.984 1.000 − 0.525 − 0.784
Significance (2-tailed) 0.527 0.204 0.723 0.229 0.401 0.456 0.102 0.354 0.619 0.463 0.114 0.000 0.648 0.427
MDA-BCL2 Correlation coefficient 0.272 0.766 0.993 0.791 0.077 0.162 0.655 0.895 0.999 0.958 0.669 − 0.525 1.000 0.940
Significance (2-tailed) 0.825 0.444 0.075 0.419 0.951 0.896 0.546 0.294 0.029* 0.185 0.534 0.648 0.000 0.221
MDA-CASP3 Correlation coefficient − 0.072 0.939 0.894 0.952 − 0.267 − 0.183 0.873 0.993 0.955 0.998 0.882 − 0.784 0.940 1.000
Significance (2-tailed) 0.954 0.223 0.296 0.198 0.828 0.883 0.325 0.073 0.192 0.036* 0.313 0.427 0.221 0.000
SKBR3-GAS5 Correlation coefficient 0.794 − 0.880 − 0.256 − 0.860 0.898 0.858 − 0.944 − 0.745 − 0.410 − 0.620 − 0.938 0.985 − 0.369 − 0.663
Significance (2-tailed) 0.416 0.315 0.835 0.341 0.289 0.344 0.214 0.465 0.731 0.574 0.226 0.112 0.760 0.539
SKBR3-MALAT1 Correlation coefficient 0.577 − 0.982 − 0.533 − 0.973 0.727 0.665 − 0.999 − 0.910 − 0.664 − 0.826 − 0.999 0.992 − 0.629 − 0.856
Significance (2-tailed) 0.608 0.123 0.642 0.148 0.482 0.537 0.021* 0.273 0.538 0.382 0.033* 0.081 0.567 0.346
SKBR3-p53 Correlation coefficient 0.132 − 0.958 − 0.865 − 0.969 0.325 0.242 − 0.901 − 0.999 − 0.935 − 0.993 − 0.909 0.820 − 0.918 − 0.998
Significance (2-tailed) 0.916 0.185 0.335 0.159 0.789 0.844 0.286 0.035* 0.231 0.074 0.274 0.388 0.260 0.038*
SKBR3-p27 Correlation coefficient 0.011 − 0.916 − 0.919 − 0.932 0.208 0.123 − 0.841 − 0.985 − 0.971 − 1.000 − 0.851 0.744 − 0.959 − 0.998
Significance (2− tailed) 0.993 0.262 0.258 0.237 0.867 0.921 0.363 0.112 0.153 0.003** 0.351 0.466 0.182 0.039*
SKBR3-BAX Correlation coefficient − 0.062 − 0.885 − 0.945 − 0.903 0.136 0.051 − 0.800 − 0.969 − 0.986 − 0.997 − 0.811 0.694 − 0.977 − 0.991
Significance (2-tailed) 0.961 0.308 0.211 0.283 0.913 0.968 0.410 0.158 0.107 0.049* 0.398 0.512 0.136 0.085
SKBR3-BCL2 Correlation coefficient 0.142 − 0.961 − 0.860 − 0.971 0.334 0.252 − 0.905 − 0.999 − 0.931 − 0.992 − 0.913 0.825 − 0.914 − 0.998
Significance (2-tailed) 0.909 0.178 0.341 0.153 0.783 0.838 0.280 0.028* 0.237 0.081 0.268 0.382 0.266 0.045*
SKBR3-CASP3 Correlation coefficient 0.925 − 0.033 0.706 0.007 0.832 0.876 − 0.191 0.202 0.581 0.366 − 0.172 0.345 0.617 0.313
Significance (2-tailed) 0.248 0.979 0.501 0.995 0.374 0.320 0.878 0.871 0.605 0.762 0.890 0.776 0.576 0.798
T47D-GAS5 Correlation coefficient 0.989 − 0.269 0.518 − 0.230 0.940 0.966 − 0.418 − 0.037 0.371 0.134 − 0.401 0.558 0.413 0.078
Significance (2-tailed) 0.096 0.827 0.654 0.852 0.222 0.167 0.725 0.977 0.758 0.914 0.737 0.623 0.729 0.950
T47D-MALAT1 Correlation coefficient 0.545 0.541 0.983 0.574 0.370 0.448 0.400 0.722 0.940 0.829 0.418 − 0.249 0.955 0.797
Significance (2-tailed) 0.633 0.636 0.117 0.611 0.759 0.704 0.738 0.486 0.221 0.377 0.726 0.840 0.192 0.413
T47D-p53 Correlation coefficient − 0.563 − 0.523 − 0.979 − 0.557 − 0.389 − 0.467 − 0.381 − 0.707 − 0.933 − 0.818 − 0.398 0.228 − 0.948 − 0.784
Significance (2-tailed) 0.619 0.650 0.130 0.624 0.746 0.691 0.751 0.500 0.234 0.391 0.739 0.853 0.205 0.427
T47D-p27 Correlation coefficient − 0.902 0.764 0.054 0.738 − 0.969 − 0.944 0.857 0.593 0.216 0.447 0.847 − 0.928 0.171 0.496
Significance (2-tailed) 0.285 0.446 0.966 0.472 0.159 0.213 0.345 0.596 0.862 0.705 0.357 0.243 0.890 0.669
T47D-BAX Correlation coefficient − 0.593 0.978 0.516 0.968 − 0.740 − 0.680 0.999 0.901 0.649 0.814 0.997 − 0.994 0.614 0.846
Significance (2-tailed) 0.596 0.135 0.655 0.161 0.470 0.524 0.034* 0.285 0.551 0.394 0.046* 0.069 0.579 0.358
T47D-BCL2 Correlation coefficient − 0.055 − 0.888 − 0.943 − 0.906 0.143 0.057 − 0.804 − 0.971 − 0.985 − 0.997 − 0.815 0.698 − 0.976 − 0.992
Significance (2-tailed) 0.965 0.304 0.216 0.279 0.909 0.963 0.405 0.154 0.111 0.045* 0.393 0.508 0.140 0.081
T47D-CASP3 Correlation coefficient 0.572 − 0.983 − 0.538 − 0.974 0.723 0.661 − 1.000 − 0.912 − 0.668 − 0.829 − 0.999 0.991 − 0.634 − 0.859
Significance (2-tailed) 0.612 0.119 0.638 0.144 0.486 0.541 0.017* 0.269 0.534 0.378 0.029* 0.085 0.563 0.342
   SKBR3-GAS5 SKBR3-MALAT1 SKBR3-p53 SKBR3-p27 SKBR3-BAX SKBR3-BCL2 SKBR3-CASP3 T47D-GAS5 T47D-MALAT1 T47D-p53 T47D-p27 T47D-BAX T47D-BCL2 T47D-CASP3
HDF-GAS5 Correlation coefficient 0.794 0.577 0.132 0.011 − 0.062 0.142 0.925 0.989 0.545 − 0.563 − 0.902 − 0.593 − 0.055 0.572
  Significance (2-tailed) 0.416 0.608 0.916 0.993 0.961 0.909 0.248 0.096 0.633 0.619 0.285 0.596 0.965 0.612
HDF-MALAT1 Correlation coefficient − 0.880 − 0.982 − 0.958 − 0.916 − 0.885 − 0.961 − 0.033 − 0.269 0.541 − 0.523 0.764 0.978 − 0.888 − 0.983
  Significance (2-tailed) 0.315 0.123 0.185 0.262 0.308 0.178 0.979 0.827 0.636 0.650 0.446 0.135 0.304 0.119
HDF-p53 Correlation coefficient − 0.256 − 0.533 − 0.865 − 0.919 − 0.945 − 0.860 0.706 0.518 0.983 − 0.979 0.054 0.516 − 0.943 − 0.538
  Significance (2-tailed) 0.835 0.642 0.335 0.258 0.211 0.341 0.501 0.654 0.117 0.130 0.966 0.655 0.216 0.638
HDF-p27 Correlation coefficient − 0.860 − 0.973 − 0.969 − 0.932 − 0.903 − 0.971 0.007 − 0.230 0.574 − 0.557 0.738 0.968 − 0.906 − 0.974
  Significance (2-tailed) 0.341 0.148 0.159 0.237 0.283 0.153 0.995 0.852 0.611 0.624 0.472 0.161 0.279 0.144
HDF-BAX Correlation coefficient 0.898 0.727 0.325 0.208 0.136 0.334 0.832 0.940 0.370 − 0.389 − 0.969 − 0.740 0.143 0.723
  Significance (2-tailed) 0.289 0.482 0.789 0.867 0.913 0.783 0.374 0.222 0.759 0.746 0.159 0.470 0.909 0.486
HDF-BCL2 Correlation coefficient 0.858 0.665 0.242 0.123 0.051 0.252 0.876 0.966 0.448 − 0.467 − 0.944 − 0.680 0.057 0.661
  Significance (2-tailed) 0.344 0.537 0.844 0.921 0.968 0.838 0.320 0.167 0.704 0.691 0.213 0.524 0.963 0.541
HDF-CASP3 Correlation coefficient − 0.944 − 0.999 − 0.901 − 0.841 − 0.800 − 0.905 − 0.191 − 0.418 0.400 − 0.381 0.857 0.999 − 0.804 − 1.000
  Significance (2-tailed) 0.214 0.021* 0.286 0.363 0.410 0.280 0.878 0.725 0.738 0.751 0.345 0.034 0.405 0.017*
MDA-GAS5 Correlation coefficient − 0.745 − 0.910 − 0.999 − 0.985 − 0.969 − 0.999 0.202 − 0.037 0.722 − 0.707 0.593 0.901 − 0.971 − 0.912
  Significance (2-tailed) 0.465 0.273 0.035* 0.112 0.158 0.028* 0.871 0.977 0.486 0.500 0.596 0.285 0.154 0.269
MDA-MALAT1 Correlation coefficient − 0.410 − 0.664 − 0.935 − 0.971 − 0.986 − 0.931 0.581 0.371 0.940 − 0.933 0.216 0.649 − 0.985 − 0.668
  Significance (2-tailed) 0.731 0.538 0.231 0.153 0.107 0.237 0.605 0.758 0.221 0.234 0.862 0.551 0.111 0.534
MDA-p53 Correlation coefficient − 0.620 − 0.826 − 0.993 − 1.000 − 0.997 − 0.992 0.366 0.134 0.829 − 0.818 0.447 0.814 − 0.997 − 0.829
  Significance (2-tailed) 0.574 0.382 0.074 0.003** 0.049* 0.081 0.762 0.914 0.377 0.391 0.705 0.394 0.045* 0.378
MDA-p27 Correlation coefficient − 0.938 − 0.999 − 0.909 − 0.851 − 0.811 − 0.913 − 0.172 − 0.401 0.418 − 0.398 0.847 0.997 − 0.815 − 0.999
  Significance (2-tailed) 0.226 0.033* 0.274 0.351 0.398 0.268 0.890 0.737 0.726 0.739 0.357 0.046* 0.393 0.029*
MDA-BAX Correlation coefficient 0.985 0.992 0.820 0.744 0.694 0.825 0.345 0.558 − 0.249 0.228 − 0.928 − 0.994 0.698 0.991
  Significance (2-tailed) 0.112 0.081 0.388 0.466 0.512 0.382 0.776 0.623 0.840 0.853 0.243 0.069 0.508 0.085
MDA-BCL2 Correlation coefficient − 0.369 − 0.629 − 0.918 − 0.959 − 0.977 − 0.914 0.617 0.413 0.955 − 0.948 0.171 0.614 − 0.976 − 0.634
  Significance (2-tailed) 0.760 0.567 0.260 0.182 0.136 0.266 0.576 0.729 0.192 0.205 0.890 0.579 0.140 0.563
MDA-CASP3 Correlation coefficient − 0.663 − 0.856 − 0.998 − 0.998 − 0.991 − 0.998 0.313 0.078 0.797 − 0.784 0.496 0.846 − 0.992 − 0.859
  Significance (2-tailed) 0.539 0.346 0.038* 0.039* 0.085 0.045* 0.798 0.950 0.413 0.427 0.669 0.358 0.081 0.342
SKBR3-GAS5 Correlation coefficient 1.000 0.954 0.707 0.616 0.557 0.714 0.504 0.695 − 0.076 0.055 − 0.979 − 0.960 0.563 0.953
  Significance (2-tailed) 0.000 0.193 0.500 0.577 0.624 0.494 0.664 0.511 0.952 0.965 0.131 0.180 0.619 0.197
SKBR3-MALAT1 Correlation coefficient 0.954 1.000 0.886 0.823 0.780 0.890 0.223 0.448 − 0.370 0.350 − 0.874 − 1.000 0.784 1.000
  Significance (2-tailed) 0.193 0.000 0.307 0.385 0.431 0.301 0.857 0.704 0.759 0.772 0.324 0.012* 0.427 0.004*
SKBR3-p53 Correlation coefficient 0.707 0.886 1.000 0.993 0.981 1.000 − 0.255 − 0.018 − 0.759 0.745 − 0.548 − 0.876 0.982 0.888
  Significance (2-tailed) 0.500 0.307 0.000 0.077 0.124 0.006** 0.836 0.989 0.452 0.465 0.631 0.320 0.119 0.304
SKBR3-p27 Correlation coefficient 0.616 0.823 0.993 1.000 0.997 0.991 − 0.370 − 0.139 − 0.832 0.820 − 0.442 − 0.812 0.998 0.826
  Significance (2− tailed) 0.577 0.385 0.077 0.000 0.046 0.084 0.759 0.911 0.374 0.388 0.708 0.397 0.042* 0.381
SKBR3-BAX Correlation coefficient 0.557 0.780 0.981 0.997 1.000 0.979 − 0.437 − 0.210 − 0.870 0.860 − 0.376 − 0.767 1.000 0.783
  Significance (2-tailed) 0.624 0.431 0.124 0.046* 0.000 0.130 0.712 0.865 0.328 0.341 0.754 0.443 0.004** 0.427
SKBR3-BCL2 Correlation coefficient 0.714 0.890 1.000 0.991 0.979 1.000 − 0.245 − 0.008 − 0.752 0.738 − 0.556 − 0.881 0.981 0.893
  Significance (2-tailed) 0.494 0.301 0.006** 0.084 0.130 0.000 0.843 0.995 0.458 0.471 0.624 0.313 0.126 0.297
SKBR3-CASP3 Correlation coefficient 0.504 0.223 − 0.255 − 0.370 − 0.437 − 0.245 1.000 0.971 0.823 − 0.835 − 0.669 − 0.242 − 0.430 0.217
  Significance (2-tailed) 0.664 0.857 0.836 0.759 0.712 0.843 0.000 0.153 0.384 0.371 0.533 0.844 0.717 0.860
T47D-GAS5 Correlation coefficient 0.695 0.448 − 0.018 − 0.139 − 0.210 − 0.008 0.971 1.000 0.665 − 0.680 − 0.827 − 0.466 − 0.204 0.443
  Significance (2-tailed) 0.511 0.704 0.989 0.911 0.865 0.995 0.153 0.000 0.537 0.524 0.380 0.692 0.869 0.708
T47D-MALAT1 Correlation coefficient − 0.076 − 0.370 − 0.759 − 0.832 − 0.870 − 0.752 0.823 0.665 1.000 − 1.000 − 0.129 0.352 − 0.867 − 0.375
  Significance (2-tailed) 0.952 0.759 0.452 0.374 0.328 0.458 0.384 0.537 0.000 0.013* 0.918 0.771 0.332 0.755
T47D-p53 Correlation coefficient 0.055 0.350 0.745 0.820 0.860 0.738 − 0.835 − 0.680 − 1.000 1.000 0.150 − 0.332 0.856 0.356
  Significance (2-tailed) 0.965 0.772 0.465 0.388 0.341 0.471 0.371 0.524 0.013* 0.000 0.904 0.785 0.346 0.769
T47D-p27 Correlation coefficient − 0.979 − 0.874 − 0.548 − 0.442 − 0.376 − 0.556 − 0.669 − 0.827 − 0.129 0.150 1.000 0.883 − 0.382 − 0.871
  Significance (2-tailed) 0.131 0.324 0.631 0.708 0.754 0.624 0.533 0.380 0.918 0.904 0.000 0.311 0.750 0.327
T47D-BAX Correlation coefficient − 0.960 − 1.000 − 0.876 − 0.812 − 0.767 − 0.881 − 0.242 − 0.466 0.352 − 0.332 0.883 1.000 − 0.771 − 1.000
  Significance (2-tailed) 0.180 0.012* 0.320 0.397 0.443 0.313 0.844 0.692 0.771 0.785 0.311 0.000 0.439 0.016*
T47D-BCL2 Correlation coefficient 0.563 0.784 0.982 0.998 1.000 0.981 − 0.430 − 0.204 − 0.867 0.856 − 0.382 − 0.771 1.000 0.787
  Significance (2-tailed) 0.619 0.427 0.119 0.042* 0.004** 0.126 0.717 0.869 0.332 0.346 0.750 0.439 0.000 0.423
T47D-CASP3 Correlation coefficient 0.953 1.000 0.888 0.826 0.783 0.893 0.217 0.443 − 0.375 0.356 − 0.871 − 1.000 0.787 1.000
  Significance (2-tailed) 0.197 0.004** 0.304 0.381 0.427 0.297 0.860 0.708 0.755 0.769 0.327 0.016* 0.423 0.000
  1. *significant at the 0.05 level
  2. **significant at the0.001 level