Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

Taherzadeh-Soureshjani, Parisa; Chehelgerdi, Mohammad

doi:10.1186/s12645-020-00066-4

Table 6 Correlation between lncRNA expression and apoptosis parameters

From: Algae-meditated route to cuprous oxide (Cu₂O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

		HDF-GAS5	HDF-MALAT1	HDF-p53	HDF-p27	HDF-BAX	HDF-BCL2	HDF-CASP3	MDA-GAS5	MDA-MALAT1	MDA-p53	MDA-p27	MDA-BAX	MDA-BCL2	MDA-CASP3
HDF-GAS5	Correlation coefficient	1.000	− 0.410	0.384	− 0.373	0.980	0.994	− 0.550	− 0.186	0.228	− 0.016	− 0.534	0.676	0.272	− 0.072
HDF-GAS5	Significance (2-tailed)	0.000	0.731	0.749	0.756	0.126	0.072	0.630	0.881	0.854	0.990	0.642	0.527	0.825	0.954
HDF-MALAT1	Correlation coefficient	− 0.410	1.000	0.685	0.999	− 0.582	− 0.510	0.987	0.972	0.794	0.918	0.990	− 0.949	0.766	0.939
HDF-MALAT1	Significance (2-tailed)	0.731	0.000	0.520	0.025	0.605	0.659	0.101	0.150	0.415	0.259	0.089	0.204	0.444	0.223
HDF-p53	Correlation coefficient	0.384	0.685	1.000	0.714	0.194	0.278	0.561	0.836	0.987	0.917	0.576	− 0.421	0.993	0.894
HDF-p53	Significance (2-tailed)	0.749	0.520	0.000	0.494	0.876	0.821	0.621	0.370	0.104	0.261	0.609	0.723	0.075	0.296
HDF-p27	Correlation coefficient	− 0.373	0.999	0.714	1.000	− 0.549	− 0.475	0.980	0.981	0.818	0.933	0.984	− 0.936	0.791	0.952
HDF-p27	Significance (2-tailed)	0.756	0.025*	0.494	0.000	0.630	0.685	0.127	0.124	0.390	0.234	0.115	0.229	0.419	0.198
HDF-BAX	Correlation coefficient	0.980	− 0.582	0.194	− 0.549	1.000	0.996	− 0.703	− 0.376	0.032	− 0.212	− 0.690	0.808	0.077	− 0.267
HDF-BAX	Significance (2-tailed)	0.126	0.605	0.876	0.630	0.000	0.055*	0.503	0.755	0.980	0.864	0.515	0.401	0.951	0.828
HDF-BCL2	Correlation coefficient	0.994	− 0.510	0.278	− 0.475	0.996	1.000	− 0.640	− 0.295	0.117	− 0.128	− 0.625	0.755	0.162	− 0.183
HDF-BCL2	Significance (2-tailed)	0.072	0.659	0.821	0.685	0.055	0.000	0.558	0.809	0.925	0.918	0.570	0.456	0.896	0.883
HDF-CASP3	Correlation coefficient	− 0.550	0.987	0.561	0.980	− 0.703	− 0.640	1.000	0.923	0.688	0.844	1.000	− 0.987	0.655	0.873
HDF-CASP3	Significance (2-tailed)	0.630	0.101	0.621	0.127	0.503	0.558	0.000	0.251	0.517	0.360	0.012*	0.102	0.546	0.325
MDA-GAS5	Correlation coefficient	− 0.186	0.972	0.836	0.981	− 0.376	− 0.295	0.923	1.000	0.914	0.985	0.930	− 0.850	0.895	0.993
MDA-GAS5	Significance (2-tailed)	0.881	0.150	0.370	0.124	0.755	0.809	0.251	0.000	0.266	0.109	0.239	0.354	0.294	0.073
MDA-MALAT1	Correlation coefficient	0.228	0.794	0.987	0.818	0.032	0.117	0.688	0.914	1.000	0.970	0.702	− 0.563	0.999	0.955
MDA-MALAT1	Significance (2-tailed)	0.854	0.415	0.104	0.390	0.980	0.925	0.517	0.266	0.000	0.156	0.505	0.619	0.029*	0.192
MDA-p53	Correlation coefficient	− 0.016	0.918	0.917	0.933	− 0.212	− 0.128	0.844	0.985	0.970	1.000	0.854	− 0.747	0.958	0.998
MDA-p53	Significance (2-tailed)	0.990	0.259	0.261	0.234	0.864	0.918	0.360	0.109	0.156	0.000	0.348	0.463	0.185	0.036*
MDA-p27	Correlation coefficient	− 0.534	0.990	0.576	0.984	− 0.690	− 0.625	1.000	0.930	0.702	0.854	1.000	− 0.984	0.669	0.882
MDA-p27	Significance (2-tailed)	0.642	0.089	0.609	0.115	0.515	0.570	0.012*	0.239	0.505	0.348	0.000	0.114	0.534	0.313
MDA-BAX	Correlation coefficient	0.676	− 0.949	− 0.421	− 0.936	0.808	0.755	− 0.987	− 0.850	− 0.563	− 0.747	− 0.984	1.000	− 0.525	− 0.784
MDA-BAX	Significance (2-tailed)	0.527	0.204	0.723	0.229	0.401	0.456	0.102	0.354	0.619	0.463	0.114	0.000	0.648	0.427
MDA-BCL2	Correlation coefficient	0.272	0.766	0.993	0.791	0.077	0.162	0.655	0.895	0.999	0.958	0.669	− 0.525	1.000	0.940
MDA-BCL2	Significance (2-tailed)	0.825	0.444	0.075	0.419	0.951	0.896	0.546	0.294	0.029*	0.185	0.534	0.648	0.000	0.221
MDA-CASP3	Correlation coefficient	− 0.072	0.939	0.894	0.952	− 0.267	− 0.183	0.873	0.993	0.955	0.998	0.882	− 0.784	0.940	1.000
MDA-CASP3	Significance (2-tailed)	0.954	0.223	0.296	0.198	0.828	0.883	0.325	0.073	0.192	0.036*	0.313	0.427	0.221	0.000
SKBR3-GAS5	Correlation coefficient	0.794	− 0.880	− 0.256	− 0.860	0.898	0.858	− 0.944	− 0.745	− 0.410	− 0.620	− 0.938	0.985	− 0.369	− 0.663
SKBR3-GAS5	Significance (2-tailed)	0.416	0.315	0.835	0.341	0.289	0.344	0.214	0.465	0.731	0.574	0.226	0.112	0.760	0.539
SKBR3-MALAT1	Correlation coefficient	0.577	− 0.982	− 0.533	− 0.973	0.727	0.665	− 0.999	− 0.910	− 0.664	− 0.826	− 0.999	0.992	− 0.629	− 0.856
SKBR3-MALAT1	Significance (2-tailed)	0.608	0.123	0.642	0.148	0.482	0.537	0.021*	0.273	0.538	0.382	0.033*	0.081	0.567	0.346
SKBR3-p53	Correlation coefficient	0.132	− 0.958	− 0.865	− 0.969	0.325	0.242	− 0.901	− 0.999	− 0.935	− 0.993	− 0.909	0.820	− 0.918	− 0.998
SKBR3-p53	Significance (2-tailed)	0.916	0.185	0.335	0.159	0.789	0.844	0.286	0.035*	0.231	0.074	0.274	0.388	0.260	0.038*
SKBR3-p27	Correlation coefficient	0.011	− 0.916	− 0.919	− 0.932	0.208	0.123	− 0.841	− 0.985	− 0.971	− 1.000	− 0.851	0.744	− 0.959	− 0.998
SKBR3-p27	Significance (2− tailed)	0.993	0.262	0.258	0.237	0.867	0.921	0.363	0.112	0.153	0.003**	0.351	0.466	0.182	0.039*
SKBR3-BAX	Correlation coefficient	− 0.062	− 0.885	− 0.945	− 0.903	0.136	0.051	− 0.800	− 0.969	− 0.986	− 0.997	− 0.811	0.694	− 0.977	− 0.991
SKBR3-BAX	Significance (2-tailed)	0.961	0.308	0.211	0.283	0.913	0.968	0.410	0.158	0.107	0.049*	0.398	0.512	0.136	0.085
SKBR3-BCL2	Correlation coefficient	0.142	− 0.961	− 0.860	− 0.971	0.334	0.252	− 0.905	− 0.999	− 0.931	− 0.992	− 0.913	0.825	− 0.914	− 0.998
SKBR3-BCL2	Significance (2-tailed)	0.909	0.178	0.341	0.153	0.783	0.838	0.280	0.028*	0.237	0.081	0.268	0.382	0.266	0.045*
SKBR3-CASP3	Correlation coefficient	0.925	− 0.033	0.706	0.007	0.832	0.876	− 0.191	0.202	0.581	0.366	− 0.172	0.345	0.617	0.313
SKBR3-CASP3	Significance (2-tailed)	0.248	0.979	0.501	0.995	0.374	0.320	0.878	0.871	0.605	0.762	0.890	0.776	0.576	0.798
T47D-GAS5	Correlation coefficient	0.989	− 0.269	0.518	− 0.230	0.940	0.966	− 0.418	− 0.037	0.371	0.134	− 0.401	0.558	0.413	0.078
T47D-GAS5	Significance (2-tailed)	0.096	0.827	0.654	0.852	0.222	0.167	0.725	0.977	0.758	0.914	0.737	0.623	0.729	0.950
T47D-MALAT1	Correlation coefficient	0.545	0.541	0.983	0.574	0.370	0.448	0.400	0.722	0.940	0.829	0.418	− 0.249	0.955	0.797
T47D-MALAT1	Significance (2-tailed)	0.633	0.636	0.117	0.611	0.759	0.704	0.738	0.486	0.221	0.377	0.726	0.840	0.192	0.413
T47D-p53	Correlation coefficient	− 0.563	− 0.523	− 0.979	− 0.557	− 0.389	− 0.467	− 0.381	− 0.707	− 0.933	− 0.818	− 0.398	0.228	− 0.948	− 0.784
T47D-p53	Significance (2-tailed)	0.619	0.650	0.130	0.624	0.746	0.691	0.751	0.500	0.234	0.391	0.739	0.853	0.205	0.427
T47D-p27	Correlation coefficient	− 0.902	0.764	0.054	0.738	− 0.969	− 0.944	0.857	0.593	0.216	0.447	0.847	− 0.928	0.171	0.496
T47D-p27	Significance (2-tailed)	0.285	0.446	0.966	0.472	0.159	0.213	0.345	0.596	0.862	0.705	0.357	0.243	0.890	0.669
T47D-BAX	Correlation coefficient	− 0.593	0.978	0.516	0.968	− 0.740	− 0.680	0.999	0.901	0.649	0.814	0.997	− 0.994	0.614	0.846
T47D-BAX	Significance (2-tailed)	0.596	0.135	0.655	0.161	0.470	0.524	0.034*	0.285	0.551	0.394	0.046*	0.069	0.579	0.358
T47D-BCL2	Correlation coefficient	− 0.055	− 0.888	− 0.943	− 0.906	0.143	0.057	− 0.804	− 0.971	− 0.985	− 0.997	− 0.815	0.698	− 0.976	− 0.992
T47D-BCL2	Significance (2-tailed)	0.965	0.304	0.216	0.279	0.909	0.963	0.405	0.154	0.111	0.045*	0.393	0.508	0.140	0.081
T47D-CASP3	Correlation coefficient	0.572	− 0.983	− 0.538	− 0.974	0.723	0.661	− 1.000	− 0.912	− 0.668	− 0.829	− 0.999	0.991	− 0.634	− 0.859
T47D-CASP3	Significance (2-tailed)	0.612	0.119	0.638	0.144	0.486	0.541	0.017*	0.269	0.534	0.378	0.029*	0.085	0.563	0.342

		SKBR3-GAS5	SKBR3-MALAT1	SKBR3-p53	SKBR3-p27	SKBR3-BAX	SKBR3-BCL2	SKBR3-CASP3	T47D-GAS5	T47D-MALAT1	T47D-p53	T47D-p27	T47D-BAX	T47D-BCL2	T47D-CASP3
HDF-GAS5	Correlation coefficient	0.794	0.577	0.132	0.011	− 0.062	0.142	0.925	0.989	0.545	− 0.563	− 0.902	− 0.593	− 0.055	0.572
	Significance (2-tailed)	0.416	0.608	0.916	0.993	0.961	0.909	0.248	0.096	0.633	0.619	0.285	0.596	0.965	0.612
HDF-MALAT1	Correlation coefficient	− 0.880	− 0.982	− 0.958	− 0.916	− 0.885	− 0.961	− 0.033	− 0.269	0.541	− 0.523	0.764	0.978	− 0.888	− 0.983
	Significance (2-tailed)	0.315	0.123	0.185	0.262	0.308	0.178	0.979	0.827	0.636	0.650	0.446	0.135	0.304	0.119
HDF-p53	Correlation coefficient	− 0.256	− 0.533	− 0.865	− 0.919	− 0.945	− 0.860	0.706	0.518	0.983	− 0.979	0.054	0.516	− 0.943	− 0.538
	Significance (2-tailed)	0.835	0.642	0.335	0.258	0.211	0.341	0.501	0.654	0.117	0.130	0.966	0.655	0.216	0.638
HDF-p27	Correlation coefficient	− 0.860	− 0.973	− 0.969	− 0.932	− 0.903	− 0.971	0.007	− 0.230	0.574	− 0.557	0.738	0.968	− 0.906	− 0.974
	Significance (2-tailed)	0.341	0.148	0.159	0.237	0.283	0.153	0.995	0.852	0.611	0.624	0.472	0.161	0.279	0.144
HDF-BAX	Correlation coefficient	0.898	0.727	0.325	0.208	0.136	0.334	0.832	0.940	0.370	− 0.389	− 0.969	− 0.740	0.143	0.723
	Significance (2-tailed)	0.289	0.482	0.789	0.867	0.913	0.783	0.374	0.222	0.759	0.746	0.159	0.470	0.909	0.486
HDF-BCL2	Correlation coefficient	0.858	0.665	0.242	0.123	0.051	0.252	0.876	0.966	0.448	− 0.467	− 0.944	− 0.680	0.057	0.661
	Significance (2-tailed)	0.344	0.537	0.844	0.921	0.968	0.838	0.320	0.167	0.704	0.691	0.213	0.524	0.963	0.541
HDF-CASP3	Correlation coefficient	− 0.944	− 0.999	− 0.901	− 0.841	− 0.800	− 0.905	− 0.191	− 0.418	0.400	− 0.381	0.857	0.999	− 0.804	− 1.000
	Significance (2-tailed)	0.214	0.021*	0.286	0.363	0.410	0.280	0.878	0.725	0.738	0.751	0.345	0.034	0.405	0.017*
MDA-GAS5	Correlation coefficient	− 0.745	− 0.910	− 0.999	− 0.985	− 0.969	− 0.999	0.202	− 0.037	0.722	− 0.707	0.593	0.901	− 0.971	− 0.912
	Significance (2-tailed)	0.465	0.273	0.035*	0.112	0.158	0.028*	0.871	0.977	0.486	0.500	0.596	0.285	0.154	0.269
MDA-MALAT1	Correlation coefficient	− 0.410	− 0.664	− 0.935	− 0.971	− 0.986	− 0.931	0.581	0.371	0.940	− 0.933	0.216	0.649	− 0.985	− 0.668
	Significance (2-tailed)	0.731	0.538	0.231	0.153	0.107	0.237	0.605	0.758	0.221	0.234	0.862	0.551	0.111	0.534
MDA-p53	Correlation coefficient	− 0.620	− 0.826	− 0.993	− 1.000	− 0.997	− 0.992	0.366	0.134	0.829	− 0.818	0.447	0.814	− 0.997	− 0.829
	Significance (2-tailed)	0.574	0.382	0.074	0.003**	0.049*	0.081	0.762	0.914	0.377	0.391	0.705	0.394	0.045*	0.378
MDA-p27	Correlation coefficient	− 0.938	− 0.999	− 0.909	− 0.851	− 0.811	− 0.913	− 0.172	− 0.401	0.418	− 0.398	0.847	0.997	− 0.815	− 0.999
	Significance (2-tailed)	0.226	0.033*	0.274	0.351	0.398	0.268	0.890	0.737	0.726	0.739	0.357	0.046*	0.393	0.029*
MDA-BAX	Correlation coefficient	0.985	0.992	0.820	0.744	0.694	0.825	0.345	0.558	− 0.249	0.228	− 0.928	− 0.994	0.698	0.991
	Significance (2-tailed)	0.112	0.081	0.388	0.466	0.512	0.382	0.776	0.623	0.840	0.853	0.243	0.069	0.508	0.085
MDA-BCL2	Correlation coefficient	− 0.369	− 0.629	− 0.918	− 0.959	− 0.977	− 0.914	0.617	0.413	0.955	− 0.948	0.171	0.614	− 0.976	− 0.634
	Significance (2-tailed)	0.760	0.567	0.260	0.182	0.136	0.266	0.576	0.729	0.192	0.205	0.890	0.579	0.140	0.563
MDA-CASP3	Correlation coefficient	− 0.663	− 0.856	− 0.998	− 0.998	− 0.991	− 0.998	0.313	0.078	0.797	− 0.784	0.496	0.846	− 0.992	− 0.859
	Significance (2-tailed)	0.539	0.346	0.038*	0.039*	0.085	0.045*	0.798	0.950	0.413	0.427	0.669	0.358	0.081	0.342
SKBR3-GAS5	Correlation coefficient	1.000	0.954	0.707	0.616	0.557	0.714	0.504	0.695	− 0.076	0.055	− 0.979	− 0.960	0.563	0.953
	Significance (2-tailed)	0.000	0.193	0.500	0.577	0.624	0.494	0.664	0.511	0.952	0.965	0.131	0.180	0.619	0.197
SKBR3-MALAT1	Correlation coefficient	0.954	1.000	0.886	0.823	0.780	0.890	0.223	0.448	− 0.370	0.350	− 0.874	− 1.000	0.784	1.000
	Significance (2-tailed)	0.193	0.000	0.307	0.385	0.431	0.301	0.857	0.704	0.759	0.772	0.324	0.012*	0.427	0.004*
SKBR3-p53	Correlation coefficient	0.707	0.886	1.000	0.993	0.981	1.000	− 0.255	− 0.018	− 0.759	0.745	− 0.548	− 0.876	0.982	0.888
	Significance (2-tailed)	0.500	0.307	0.000	0.077	0.124	0.006**	0.836	0.989	0.452	0.465	0.631	0.320	0.119	0.304
SKBR3-p27	Correlation coefficient	0.616	0.823	0.993	1.000	0.997	0.991	− 0.370	− 0.139	− 0.832	0.820	− 0.442	− 0.812	0.998	0.826
	Significance (2− tailed)	0.577	0.385	0.077	0.000	0.046	0.084	0.759	0.911	0.374	0.388	0.708	0.397	0.042*	0.381
SKBR3-BAX	Correlation coefficient	0.557	0.780	0.981	0.997	1.000	0.979	− 0.437	− 0.210	− 0.870	0.860	− 0.376	− 0.767	1.000	0.783
	Significance (2-tailed)	0.624	0.431	0.124	0.046*	0.000	0.130	0.712	0.865	0.328	0.341	0.754	0.443	0.004**	0.427
SKBR3-BCL2	Correlation coefficient	0.714	0.890	1.000	0.991	0.979	1.000	− 0.245	− 0.008	− 0.752	0.738	− 0.556	− 0.881	0.981	0.893
	Significance (2-tailed)	0.494	0.301	0.006**	0.084	0.130	0.000	0.843	0.995	0.458	0.471	0.624	0.313	0.126	0.297
SKBR3-CASP3	Correlation coefficient	0.504	0.223	− 0.255	− 0.370	− 0.437	− 0.245	1.000	0.971	0.823	− 0.835	− 0.669	− 0.242	− 0.430	0.217
	Significance (2-tailed)	0.664	0.857	0.836	0.759	0.712	0.843	0.000	0.153	0.384	0.371	0.533	0.844	0.717	0.860
T47D-GAS5	Correlation coefficient	0.695	0.448	− 0.018	− 0.139	− 0.210	− 0.008	0.971	1.000	0.665	− 0.680	− 0.827	− 0.466	− 0.204	0.443
	Significance (2-tailed)	0.511	0.704	0.989	0.911	0.865	0.995	0.153	0.000	0.537	0.524	0.380	0.692	0.869	0.708
T47D-MALAT1	Correlation coefficient	− 0.076	− 0.370	− 0.759	− 0.832	− 0.870	− 0.752	0.823	0.665	1.000	− 1.000	− 0.129	0.352	− 0.867	− 0.375
	Significance (2-tailed)	0.952	0.759	0.452	0.374	0.328	0.458	0.384	0.537	0.000	0.013*	0.918	0.771	0.332	0.755
T47D-p53	Correlation coefficient	0.055	0.350	0.745	0.820	0.860	0.738	− 0.835	− 0.680	− 1.000	1.000	0.150	− 0.332	0.856	0.356
	Significance (2-tailed)	0.965	0.772	0.465	0.388	0.341	0.471	0.371	0.524	0.013*	0.000	0.904	0.785	0.346	0.769
T47D-p27	Correlation coefficient	− 0.979	− 0.874	− 0.548	− 0.442	− 0.376	− 0.556	− 0.669	− 0.827	− 0.129	0.150	1.000	0.883	− 0.382	− 0.871
	Significance (2-tailed)	0.131	0.324	0.631	0.708	0.754	0.624	0.533	0.380	0.918	0.904	0.000	0.311	0.750	0.327
T47D-BAX	Correlation coefficient	− 0.960	− 1.000	− 0.876	− 0.812	− 0.767	− 0.881	− 0.242	− 0.466	0.352	− 0.332	0.883	1.000	− 0.771	− 1.000
	Significance (2-tailed)	0.180	0.012*	0.320	0.397	0.443	0.313	0.844	0.692	0.771	0.785	0.311	0.000	0.439	0.016*
T47D-BCL2	Correlation coefficient	0.563	0.784	0.982	0.998	1.000	0.981	− 0.430	− 0.204	− 0.867	0.856	− 0.382	− 0.771	1.000	0.787
	Significance (2-tailed)	0.619	0.427	0.119	0.042*	0.004**	0.126	0.717	0.869	0.332	0.346	0.750	0.439	0.000	0.423
T47D-CASP3	Correlation coefficient	0.953	1.000	0.888	0.826	0.783	0.893	0.217	0.443	− 0.375	0.356	− 0.871	− 1.000	0.787	1.000
	Significance (2-tailed)	0.197	0.004**	0.304	0.381	0.427	0.297	0.860	0.708	0.755	0.769	0.327	0.016*	0.423	0.000

*significant at the 0.05 level
**significant at the0.001 level

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ISSN: 1868-6966

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