Fig. 7

Protein and mRNA expression of p21, p53, and E/N-cadherins in Hela cells after 24 h (top) or 48 h (bottom). Cells were analyzed by western blot and qPCR. a, d Effect of SAHA and SAHA-loaded nanomicelles on the protein expression of the four markers in Hela cells at 24 and 48 h. b, e mRNA analysis of p21 and p53 markers on Hela cells at 24 and 48 h. c, f Effect of SAHA and SAHA-loaded nanomicelles on E and N-cadherin mRNA expression in Hela cells at both time points. Data were normalized to the level of GAPDH. Data were tested by T test for statistical significance (n = 3, *p < 0.05, **p < 0.01, ***p < 0.001)