Fig. 8

pH-dependent doxorubicin releasing behaviour, and pharmacokinetics in vivo and in vitro. a At pH:5, half of the drug is released from nanocomposite in the releasing medium after 85 min, while at pH: 7.5 half of the drug is released from nanocomposite in the releasing medium after 85 min (d). b Targeted delivery at 24 h shows the maximum concentration as compared to non-targeted delivery at 24 h. At 6 h no significant difference was observed. e In vitro doxorubicin concentration in culture medium and dead cells after different time points (GNP theranostic nanomedicine). Results show the increase in concentration at 12 h, then decreases a little. Maximum concentration is shown at 72 h. c Olasma drug activity profile of doxorubicin (GNP theranostic nanomedicine) after IV administration at different time points and f plasma drug activity profile of doxorubicin (GNP theranostic nanomedicine) after PO. Data represented in mean (n = 3) with standard deviation and p value < 0.001)