Fig. 4

Knockdown of ubiquitin B expression in SKOV3-GFP cells inhibited ovarian cancer cell proliferation and migration. a Downregulation of UBB significantly inhibited the proliferation of cells, meanwhile, nanoparticle 5A2SC8 had little toxicity to cell. The viability of cells was above 90% when cells were treated with 5A2SC8 alone or Ctrl-5A2SC8. b, c The migration of cells was decreased when treated with si-UBB-5A2SC8 for 48 h or 72 h, the width of wound was significantly enlarged when compared with PBS and si-Ctrl-5A2SC8. *P < 0.05. Scale bar: 50 μm