Hyaluronan self-agglomerating nanoparticles for non-small cell lung cancer targeting

Cancer Nanotechnology

Table 3 Stoichiometric ratio of trivalent transition metallic ions and hyaluronan

Volume of 0.05 M Fe³⁺ ion (µL)	v/v (%)	Stoichiometric ratio (HA disaccharide: Fe³⁺)	Size (nm)	% SD	PDI	pH value
0.3% Hyaluronan and FeCl₃
400	0.0260	1:0.17	542	–	0.416	2.58
420	0.0272	1:0.18	424	–	0.277	2.58
440	0.0285	1:0.19	492	–	0.352	2.57
460	0.0298	1:0.19	479	–	0.306	2.58
480	0.0310	1:0.20	428	–	0.236	2.58
500	0.0323	1:0.21	407	–	0.214	2.57
520	0.0335	1:0.22	392	–	0.217	2.57
0.1% Hyaluronan and FeCl₃
140	0.0092	1:0.18	142	4.74	0.365	2.93
150	0.0099	1:0.19	130	7.58	0.208	2.92
160	0.0106	1:0.20	97.8	4.28	0.212	2.90
180	0.0119	1:0.23	88.5	3.20	0.176	2.88
200	0.0132	1:0.25	93.9	3.01	0.143	2.86
220	0.0145	1:0.28	101	1.98	0.128	2.84
240	0.0157	1:0.30	110	2.58	0.090	2.82
260	0.0170	1:0.33	120	1.87	0.157	2.80
280	0.0183	1:0.35	122	4.37	0.144	2.78
300	0.0196	1:0.38	137	1.86	0.127	2.77
310	0.0202	1:0.39	177	0.50	0.252	2.77
320	0.0209	1:0.40	233	1.52	0.262	2.76

ISSN: 1868-6966