Table 1 Independent variables and levels involved in Box–Behnken design
From: Nanomicelles co-loaded with doxorubicin and salvianolic acid A for breast cancer chemotherapy
Independent variable | Level | ||
|---|---|---|---|
Low (− 1) | Medium (0) | High (+ 1) | |
X1 types of polymer | mPEG-PLA | mPEG-PCL | mPEG-PCL-Phe(Boc) |
X2 mass ratio of DOX/SAA | 1:2 | 1:4 | 1:6 |
X3 feed ratio | 4:1 | 5:1 | 8:1 |