Table 2 Effects of Tween-80:Tween-60:cholesterol:DOTAP:PEG ratios on the PDI, diameter size (nm), and Zeta potential (mV) of the miRNA-loaded system
Code | Tween-80 | Tween-60 | cholesterol | DOTAP% | PEG% | PDI | Zeta (mv) | Diameter (nm) |
|---|---|---|---|---|---|---|---|---|
F1 | 90 | 0 | 10 | – | – | 0.21 ± 0.12 | − 22 ± 0.13 | 116 ± 0.44 |
F2 | 0 | 90 | 10 | – | – | 0.23 ± 0.42 | − 21 ± 0.44 | 113 ± 0.98 |
F3 | 75 | 15 | 10 | – | – | 0.19 ± 0.005 | − 23 ± 0.65 | 100 ± 0.023 |
F4 | 70 | 15 | 10 | – | 5 | 0.18 ± 0.36 | − 27 ± 0.098 | 95 ± 0.033 |
F5 | 70 | 15 | 10 | 5 | – | 0.15 ± 0.65 |  + 15 ± 0.53 | 81 ± 0.004 |
F6.2 | 62.5 | 12.5 | 7 | 15 | 5 | 0.13 ± 0.045 |  + 23 ± 0.11 | 72 ± 0.42 |