Fig. 4
From: Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma
Ponatinib injection and toxicity. Histological section of mice heart, lung and liver after Pon IV (a) vs. IP (b) injections compared to control (no treatment). All sections were stained with hematoxylin–eosin. Mice were injected with Pon 2 times a week. Scale bar = 10 μm (highlighted frame scale bar = 100 μm, black arrow = immune cell infiltration, black circle area = necrotic area)