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Table 1 List of compounds NCI Approved Oncology Drug Set V

From: Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma

Name

Library set

Concentration (mM)

Activity

Hydroxyurea

NCI Approved Oncology Drug Set V

10

RNA inhibitor

Temozolomide

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Carmustine

NCI Approved Oncology Drug Set V

10

Alkylating agent

Ifosfamide

NCI Approved Oncology Drug Set V

10

Alkylating agent

Anastrozole

NCI Approved Oncology Drug Set V

10

Aromatase inhibitor

Pipobroman

NCI Approved Oncology Drug Set V

10

Alkylating agent

Axitinib

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor

Dasatinib

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor

Vandetanib

NCI Approved Oncology Drug Set V

10

Kinase inhibitor

Ponatinib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Allopurinol

NCI Approved Oncology Drug Set V

10

Purine analog, purine synthesis inhibitor

Busulfan

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Cyclophosphamide

NCI Approved Oncology Drug Set V

10

Alkylating agent

Cisplatin

NCI Approved Oncology Drug Set V

10

DNA crosslinking agent

Letrozole

NCI Approved Oncology Drug Set V

10

Aromatase inhibitor

Megestrol acetate

NCI Approved Oncology Drug Set V

10

Progestin

Mitoxantrone

NCI Approved Oncology Drug Set V

10

Topo II inhibitor

Pazopanib hydrochloride

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor

Vemurafenib

NCI Approved Oncology Drug Set V

10

RAF/MEK inhibitor

Cabozantinib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Fluorouracil

NCI Approved Oncology Drug Set V

10

Thymidylate synthesis inhibitor (antimetabolite)

Altretamine

NCI Approved Oncology Drug Set V

10

Alkylating agent

Uracil mustard

NCI Approved Oncology Drug Set V

10

Alkylating agent

Tretinoin

NCI Approved Oncology Drug Set V

10

ATRA

Lenalidomide

NCI Approved Oncology Drug Set V

10

(Unknown, alter cytokine production)

Bendamustine hydrochloride

NCI Approved Oncology Drug Set V

10

Alkylating agent

Pemetrexed

NCI Approved Oncology Drug Set V

10

Folate antimetabolite

Imatinib

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor

Regorafenib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Bosutinib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Thiouanine

NCI Approved Oncology Drug Set V

10

Purine analog (antimetabolite)

Floxuridine

NCI Approved Oncology Drug Set V

10

Antimetabolite

Cytarabine hydrochloride

NCI Approved Oncology Drug Set V

10

DNA/RNA synthesis inhibitor

Dexrazoxane

NCI Approved Oncology Drug Set V

10

EDTA derivative

Pomalidomide

NCI Approved Oncology Drug Set V

10

Immunomodulator

Fludarabine phosphate

NCI Approved Oncology Drug Set V

10

Purine analog (antimetabolite)

Gefitinib

NCI Approved Oncology Drug Set V

10

EGFR inhibitor

Sorafenib

NCI Approved Oncology Drug Set V

10

Tyrosine-raf- and ser/thr kinase inhibitor

Idarubicin hydrochloride

NCI Approved Oncology Drug Set V

10

Anthracycline

Daunorubicin hydrochloride

NCI Approved Oncology Drug Set V

10

RNA/DNA synthesis inhibitor

Mercaptopurine

NCI Approved Oncology Drug Set V

10

DNA/RNA synthesis inhibitor

Methoxsalen

NCI Approved Oncology Drug Set V

10

Furanocoumarins

Thalidomide

NCI Approved Oncology Drug Set V

10

(unknown, alter cytokine production)

Pentostatin

NCI Approved Oncology Drug Set V

10

Antimetabolite

Chlorambucil

NCI Approved Oncology Drug Set V

10

Alkylating agent

Bortezomib

NCI Approved Oncology Drug Set V

10

Proteasome inhibitor

Vismodegib

NCI Approved Oncology Drug Set V

10

GLI1/GLI2 inhibitors

Raloxifene

NCI Approved Oncology Drug Set V

10

SERM

Nilotinib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Doxorubicin hydrochloride

NCI Approved Oncology Drug Set V

10

DNA intercalating agent

Mechlorethamine hydrochloride

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Lomustine

NCI Approved Oncology Drug Set V

10

Alkylating agent

Procarbazine hydrochloride

NCI Approved Oncology Drug Set V

10

Alkylating agent

Nelarabine

NCI Approved Oncology Drug Set V

10

DNA synthesis inhibitor

Mitomycin

NCI Approved Oncology Drug Set V

10

DNA crosslinking agent

Capecitabine

NCI Approved Oncology Drug Set V

10

Pyrimidine analogue

Crizotinib

NCI Approved Oncology Drug Set V

10

Protein kinase inhibitor

Afatinib

NCI Approved Oncology Drug Set V

10

Angiokinase inhibitor

Ixabepilone

NCI Approved Oncology Drug Set V

10

MT stabilizing agent

Etoposide

NCI Approved Oncology Drug Set V

10

Topo inhibitor

Thiotepa

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Azacitidine

NCI Approved Oncology Drug Set V

10

Inhibitor of DNMTs

Streptozocin

NCI Approved Oncology Drug Set V

10

Alkylating agent

Vorinostat

NCI Approved Oncology Drug Set V

10

HDAC inhibitor

Mitotane

NCI Approved Oncology Drug Set V

10

Unknown (interferes with steroid synthesis)

Celecoxib

NCI Approved Oncology Drug Set V

10

Cox-2 inhibitor

Methotrexate

NCI Approved Oncology Drug Set V

10

Antimetabolite

Pralatrexate

NCI Approved Oncology Drug Set V

10

Antimetabolite

Romidepsin

NCI Approved Oncology Drug Set V

10

HDAC inhibitor

Tamoxifen citrate

NCI Approved Oncology Drug Set V

10

Anti-ER compound

Aminolevulinic acid hydrochloride

NCI Approved Oncology Drug Set V

10

Involved in porphyrin synthesis, used as a photodynamic therapy

Decitabine

NCI Approved Oncology Drug Set V

10

Inhibitor of DNMTs

Cladribine

NCI Approved Oncology Drug Set V

10

Purine analog (DNA synthesis inhibitor)

Exemestane

NCI Approved Oncology Drug Set V

10

Aromatase inhibitor

Clofarabine

NCI Approved Oncology Drug Set V

10

Nucleoside antimetabolite

Sunitinib

NCI Approved Oncology Drug Set V

10

RTK inhibitor

Topotecan hydrochloride

NCI Approved Oncology Drug Set V

10

Topo inhibitor

Enzalutamide

NCI Approved Oncology Drug Set V

10

Androgen receptor inhibitor

Omacetaxine mepesuccinate

NCI Approved Oncology Drug Set V

10

Protein translation inhibitor

Epirubicin hydrochloride

NCI Approved Oncology Drug Set V

10

DNA intercalating agent

Estramustine phosphate sodium

NCI Approved Oncology Drug Set V

10

Depolymerizes MTs, also metabolized to E2 and E1 in the liver

Carfilzomib

NCI Approved Oncology Drug Set V

10

Proteasome inhibitor

Dactinomycin

NCI Approved Oncology Drug Set V

10

RNA PolII inhibitor

Dacarbazine

NCI Approved Oncology Drug Set V

10

Alkylates DNA

Melphalan hydrochloride

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Lapatinib

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor

Docetaxel

NCI Approved Oncology Drug Set V

10

Taxane (MT stabilizer)

Plicamycin

NCI Approved Oncology Drug Set V

10

(Mithramycin) RNA synthesis inhibitor

Arsenic trioxide

NCI Approved Oncology Drug Set V

10

APL treatment (in combination with ATRA)

Abiraterone

NCI Approved Oncology Drug Set V

10

CYP17 inhibitor (reduces testosterone levels)

Irinotecan hydrochloride

NCI Approved Oncology Drug Set V

10

Topo I inhibitor

Cabazitaxel

NCI Approved Oncology Drug Set V

10

Taxol derivative

Bleomycin sulfate

NCI Approved Oncology Drug Set V

10

DNA breaks

Triethylenemelamine

NCI Approved Oncology Drug Set V

10

DNA alkylating agent

Fulvestrant

NCI Approved Oncology Drug Set V

10

SERM

Paclitaxel

NCI Approved Oncology Drug Set V

10

MT stabilizer

Vinorelbine tartrate

NCI Approved Oncology Drug Set V

10

MT inhibitor

Carboplatin

NCI Approved Oncology Drug Set V

10

DNA intercalating agent

Trametinib

NCI Approved Oncology Drug Set V

10

MEK inhibitor

Vinblastine sulfate

NCI Approved Oncology Drug Set V

10

MT inhibitor

Temsirolimus

NCI Approved Oncology Drug Set V

10

mTOR inhibitor

Erlotinib hydrochloride

NCI Approved Oncology Drug Set V

10

Tyrosine kinase inhibitor (EGFR specific)

Dabrafenib mesylate

NCI Approved Oncology Drug Set V

10

ATP-competitive kinase inhibitor and targets the MAPK pathway

Vincristine sulfate

NCI Approved Oncology Drug Set V

10

MT disruptor

Gemcitabine hydrochloride

NCI Approved Oncology Drug Set V

10

(Nucleoside analog) inhibits DNA synthesis

Amifostine

NCI Approved Oncology Drug Set V

10

DNA intercalating agent

Teniposide

NCI Approved Oncology Drug Set V

10

Topo II inhibitor

Sirolimus

NCI Approved Oncology Drug Set V

10

(Rapamycin) mTOR inhibitor

Imiquimod

NCI Approved Oncology Drug Set V

10

TLR7 agonist

Zoledronic acid

NCI Approved Oncology Drug Set V

10

Bisphosphonate (prevents bone resorption)

Valrubicin

NCI Approved Oncology Drug Set V

10

Topo II inhibitor

Everolimus

NCI Approved Oncology Drug Set V

10

mTOR inhibitor

Plerixafor

NCI Approved Oncology Drug Set V

10

CXCR4 blocker

Oxaliplatin

NCI Approved Oncology Drug Set V

10

DNA synthesis inhibitor

  1. Screening data from the Approved Oncology Drug Set V Library
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Cancer Nanotechnology

ISSN: 1868-6966

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