Fig. 3

Micrographs of chronic active cholangitis in hamster livers with obstructive cholestasis from the group infected with Opisthorchis viverrini and receiving NDMA, at 5 months. A, B overview of generalized cholangitis lesions in chronic obstructive cholestasis in opisthorchiasis, A H&E stain and B stained for cytokeratin 19, inset boxes indicate perihilar areas. C, D Chronic active cholangitis (black arrows) at the perihilar area, C H&E stain and D cytokeratin 19. E Chronic active cholangitis of peripheral bile ducts at the subcapsular area, showing inflammatory exudates in bile duct lumens and mixed inflammatory cell infiltration in periductal and interstitial tissue. F peripheral bile ducts at the subcapsular area, F, left reveals chronic cholangitis and F, right reveals healed cholangitis foci