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Scheme 1 | Cancer Nanotechnology

Scheme 1

From: Low-dose pleiotropic radiosensitive nanoformulations for three-pronged radiochemotherapy of hypoxic brain glioblastoma under BOLD/DWI monitoring

Scheme 1

The schematic illustration of SLC-AN/SN@AQ NPs for three-pronged hypoxic radiosensitization of brain gliomas under BOLD/DWI monitoring. Benefiting from angiopep-2-mediated brain delivery, this nanoformulation enables an efficient combination of high Z-atom-dependent dose deposition enhancement, NO-mediated hypoxia relief, and AQ4N-induced hypoxia-activated chemotherapy under low-dose radiation. Meanwhile, in vivo 9.4 T BOLD/DWI realizes real-time dynamic assessment of local oxygen supply and treatment response of brain gliomas

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Cancer Nanotechnology

ISSN: 1868-6966

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