Fig. 4

MNPs as an effective in vivo heat mediator under AMF. A Infrared camera images of the colon tumor mice during 20 min of Oncothermia, B The profile of temperature variations the CT26 tumor-bearing mice treated with intravenous injection of 600 mg/kg MNPs in the presence or absence of AMF (13.56 MHz, 40 A/m, 20 min) as a function of time. In the presence of a magnetic field, the antitumor efficacy of free 5-Fu and 5-Fu/MNPs was determined in the CT26 colorectal tumor model, C Tumor volume in different treatment groups, D Kaplan–Meier plot