Fig. 6
From: Functional targeted therapy for glioma based on platelet membrane-coated nanogels
in vivo tumour suppression in orthotopic glioma model mice. A An orthotopic glioma model was established with the C6 cell line in 4 to 6‐week‐old nude male mice. Control, DOX, DOX@NGs, and DOX@PNGs were intravenously injected 7 day post‐tumour implantation at the indicated days. The tumour tissues were collected for analysing the blood gain and organs (HE and IHC staining) 1 day after the final injection. B IVIS images of glioma growth in mice on the 7th, 10th, 13th, 16th, and 19th day after injection with as-fabricated NPs; red = strong fluorescence signal. C Schematic map of mice brain anatomical specimen. D Survival curve of mice in each group; n = 7; *p < 0.05, ***p < 0.001. E HE staining, IHC staining, and CD34-PAS double staining of mouse brain tissue after different treatments. Scale bar = 50 μm