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Table 2 Pharmacokinetic parameters of the free Dox and Dox-loaded liposomal formulations

From: Doxorubicin-loaded liposomes surface engineered with the matrix metalloproteinase-2 cleavable polyethylene glycol conjugate for cancer therapy

Treatment group

MRT (h)

AUMC (µg*h2/mL)

AUC (µg*h/mL)

Cl (mg)/(µg/mL)/h

Vss (mg)/(µg/mL)

t1/2 (h)

K (1/h)

Dox

3.98

28.7

7.2

1.39

7.25

3.62

0.19

Caelyx®

15.87

23,089.1

1454

0.007

0.11

12.18

0.056

F4

11.73

2710.6

231

0.043

0.51

9.71

0.071

F5

22.66

18,809.7

830

0.012

0.27

16.42

0.042

F6

27.52

17,748.5

645

0.012

0.42

19.18

0.036

  1. F4: DOTAP/HSPC/DOPE/Chol/α-tocopherol (10/50/2/38/0.2), F5: DOTAP/HSPC/Chol/DOPE-peptide-PEG/α-tocopherol (10/49.5/38/2.5/0.2), F6: DOTAP/HSPC/Chol/ DOPE-peptide-PEG/α-tocopherol (10/47/38/5/0.2)
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Cancer Nanotechnology

ISSN: 1868-6966

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