Fig. 1

Schematic illustration of designing MnO₂-C/M-HA for photo-chemo-immunotherapy. MnO₂ degrades after reaction in acidic environment, releasing Ce6 and MTZ. Under the irradiation of 660 nm near-infrared laser, Ce6 is activated and induces ROS production. MTZ also plays a role in both chemotherapy and PTT. Synergistically stimulate tumor cells to release DMAPs, promote DCs maturation, and further induce anti-tumor immune response