Fig. 5
Antitumor efficiency of MnO2-C/M-HA in 4T1 tumor-bearing BALB/c mice. a Schematic illustration of treatment schedule for 4T1 tumor-bearing BALB/c mice. b Tumor growth curves of different groups during the therapeutic course of 14 days. c Photographs of excised solid tumors at the end of anti-tumor studies. d Tumor weights of different groups at the endpoints of treatment schedule. e Body weight changes of 4T1 tumor-bearing BALB/c mice of different groups during the treatment. f Histopathological analysis: immunohistochemical or immunofluorescence staining of the sections from excised tumors on day 14 in terms of H&E and TUNEL. Scale bars: 100 μm for H&E and 200 μm for TUNEL. g-h Semi-quantitative statistical analysis of H&E staining and TUNEL staining of tumor tissue slices. All the data were displayed as mean ± SD (*p < 0.05, **p < 0.01 and ****p < 0.0001)