Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer

Table 1 Synthetic details and results were obtained from NMR, SEC, and CMC measurements

Polymer	Conv^a [%]	M_n^b [kg mol⁻¹]	Đ^b	CMC [mg mL⁻¹]
chol-PNIPAAm-X (P1)	99	26.42	1.10	0.0330
chol-PAcacP-X (P2)	95	5.65^c	–	–
chol-PNIPAAm-b-PAcacP-X (P3)	> 99	29.47	1.07	0.0048
chol-P(NIPAAm-s-AcacP)-X (P4)	> 99	32.09	1.04	0.0110
chol-PAcacP-b-PNIPAAm-X (P5)	90	26.64	1.30	0.0050

^aMonomer conversion determined by ¹H NMR
^bMeasured by SEC-RI-MALS
^cCalculated from ¹H NMR. All polymerizations were carried out at 70 °C for 24 h, and AIBN was added as 10 mol% of CTA

ISSN: 1868-6966