Table 2 Physicochemical parameters of empty and doxorubicin-loaded nanoparticles
Polymer | MADLS [nm] | Horizontal size [nm] | Vertical size [nm] | Zeta potential [mV] | Tg [°C] | TCP [°C] | Tagg [°C] | CDOXa [µM] |
|---|---|---|---|---|---|---|---|---|
PNP1 | 21.8 ± 3.0 | 17.7 | 13.6 | − 6.8 | 132.5 | 34.0 | 30.5 |  |
PNP1_DOX | 24.1 ± 1.7 | 25.7 | 10.2 | − 8.0 | 140.7 | 35.0 | 31.0 | 0.626 |
PNP3 | 99.7 ± 12.9 | 78.7 | 75.5 | − 5.5 | 132.5 | 34.0 | 30.5 |  |
PNP3_DOX | 42.6 ± 2.8 | 29.1 | 28.1 | − 24.2 | 132.2 | 33.5 | 30.5 | 0.163 |
PNP4 | 81.9 ± 5.0 | 59.0 | 18.5 | − 3.7 | 131.8 | 30.5 | 29.0 |  |
PNP4_DOX | 86.4 ± 3.8 | 57.3 | 64.5 | − 6.7 | 132.4 | 30.5 | 28.5 | 0.077 |
PNP5 | 30.1 ± 1.6 | 67.0 | 93.5 | − 4.9 | 138.3 | 32.5 | 30.0 |  |
PNP5_DOX | 41.6 ± 1.3 | 32.4 | 28.6 | − 7.9 | 139.8 | 33.0 | 30.0 | 0.190 |