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Fig. 4 | Cancer Nanotechnology

Fig. 4

From: Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer

Fig. 4

Effects of BU@MMs on the migration and invasion of A2780 and SKOV3 cells. a, b Representative images of migrating A2780 and SKOV3 cells. Bar charts showing the number of migrating A2780 (c) and SKOV3 (d) cells. e, f Representative images of the invasion of A2780 and SKOV3 cells. Bar charts showing the number of invaded A2780 (g) and SKOV3 (h) cells. i, j Tube formation by HUVECs cultured on Matrigel compared to the tube formation by A2780 and SKOV3 cells. Bar charts showing the total segment lengths in A2780 (k) and SKOV3 (l) cells. Expression of proteins related to the EMT pathway in A2780 (m) and SKOV3 cells (n), including E-cadherin, n-cadherin, vimentin, Snail, MMP-2, MMP-9 and VEGF. Bar: 100 µm. Data are presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001 indicate statistical significance compared with the control

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Cancer Nanotechnology

ISSN: 1868-6966

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