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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer

Fig. 5

Inhibitory effect of BU@MMs on ovarian cancer intraperitoneal metastasis in vivo. a The timeline of the animal experiment. b Representative images of the abdominal circumferences of the mice on the 40th day. c, d Abdominal circumferences and body weights during the period of treatment. e Representative images of metastatic tumor nodules from the intraperitoneal cavity. The number of metastatic tumor nodules in the intraperitoneal cavity (f), including the abdominal wall (g), intestines (h), and diaphragm (i). j The color of the ascites in the BU@MMs and Ctrl groups. k Ascites volume. l H&E-stained histological images of mouse intestines from various groups. The concentrations of MMP-2 (m), MMP-9 (n), and VEGF (o) in mouse serum. Bar: 200 µm. The data are presented as the mean ± SD (n = 6). *P < 0.05, **P < 0.01 and ***P < 0.001 indicate statistical significance compared with the control

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Cancer Nanotechnology

ISSN: 1868-6966

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