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Table 4 48 h incubation half inhibitory effect (IC50) of the free and nano-RX regimens and their cytotoxic and IC50 fold changes

From: Hyaluronated nanoparticles deliver raloxifene to CD44-expressed colon cancer cells and regulate lncRNAs/miRNAs epigenetic cascade

Parameters

Cell lines

Free and nano-regimens

RX

RX-CS NPs (F1)

RX-CS NPs (F2)

RX-HA-CS NPs

IC50, µM

Caco-2 cells

55.99

46.23

49.99

20.61

HCT 116 cells

79.38

35.27

44.03

36.65

WI-38 cells

65.14

77.41

74.65

 ND

Cytotoxic fold

Caco-2 cells

Ref.

1.211

1.120

2.717

HCT 116 cells

Ref.

2.251

1.803

2.166

WI-38 cells

Ref.

0.841

0.873

ND

IC50 fold

Caco-2 cells

Ref.

0.826

0.893

0.368

HCT 116 cells

Ref.

0.444

0.555

0.462

WI-38 cells

Ref.

1.188

1.146

ND

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Cancer Nanotechnology

ISSN: 1868-6966

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