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Fig. 1 | Cancer Nanotechnology

Fig. 1

From: Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes

Fig. 1

Overall conjugation chemistry and characterization of the CNT conjugates. A The two-step conjugation of anti-TSHR antibodies onto the surface of CNTs. Step 1: The heterobifunctional maleimide-PEG5000-NH2 crosslinker is conjugated onto the EDC/NHS activated MWCNT surface. Step 2: The thiol group on anti-TSHR antibodies reacts with the maleimide terminal end of the CNT-PEG5000. B The characterization of different CNT formulations with FT-IR, Raman spectrum, and UV–Vis spectroscopy. A small peak, indicated by a circle, near 1750 cm−1 corresponding to carboxylic acids is observed in FT-IR spectra after CNT oxidation. Conjugation of antibodies and Cy5.5 is confirmed with Raman spectrum and UV–Vis spectroscopy, respectively. C TEM images of different CNT formulations. Scale bar sizes represent 200 nm

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Cancer Nanotechnology

ISSN: 1868-6966

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