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Fig. 3 | Cancer Nanotechnology

Fig. 3

From: Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes

Fig. 3

In vivo tumor accumulation and biodistribution profiles. A IVIS was used to monitor the tumor and organ biodistribution profiles of αTSHR; Cy5.5-MWCNT and IgG; Cy5.5-MWCNT 24 h post-intravenous injection, where T = tumor, L = liver, K = kidneys, S = spleen, H = heart, Lu = lungs. B Significant improvement in the accumulation of the αTSHR-labeled CNTs was observed in the tumor (1.22-fold increase, p = 0.0376), while fluorescence at other major organs remained unchanged. C The accumulation of CNTs at the tumor post-intravenous injection for a week. D Enhanced accumulation of αTSHR; Cy5.5-MWCNT was observed at the tumor throughout the observed period compared to IgG; Cy5.5-MWCNT (p = 0.046, 0.049, 0.019, and 0.043 for 24, 48, 72 and 144 h, respectively)

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Cancer Nanotechnology

ISSN: 1868-6966

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