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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon nanotubes

Fig. 5

In vivo temperature monitoring and xenograft tumor ablation. A The temperature of the surface of the tumor upon laser irradiation was monitored using FLIR thermal camera. B Documentation of the surface temperature of those injected with αTSHR; Cy5.5-MWCNT over other groups. A significant increase in temperature was observed (p < 0.01 for all). C The size of the tumor after laser irradiation was monitored for five weeks. Those that were administered with αTSHR; Cy5.5-MWCNT saw near-complete tumor ablation, while the other groups had tumor recurrence. D Survival outcomes were assessed by tumor size recurrence of the different treatment cohorts. E H&E staining and human mitochondrial staining of the tumors. Scale bar = 100 µm. F Quantification of the human mitochondrial staining, post 24 h irradiation. Those that received αTSHR;Cy5.5-MWCNT + laser treatment protocol saw a significant decrease in the mitochondrial staining signal (p < 0.001 vs. no treatments, p < 0.05 vs. NIR alone or IgG;Cy5.5-MWCNT), underscoring the selective ablation of the TSHR-targeted BCPAP tumors

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Cancer Nanotechnology

ISSN: 1868-6966

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