Fig. 7
(a) Representative immunofluorescence images of 53BP1 foci in FaDu cells 24 h post-radiation (2 Gy) under 21% O2 and 0.5% O2. Cells were treated with either AuNPs (100 μg), atovaquone (AQ 30 μM) or the combination. Panels b and c represent the mean 53BP1 foci 24 h post-radiation (0 or 2 Gy) in FaDu cells after treatment with AuNPs, atovaquone or the combination under atmospheric oxygen levels (b) and hypoxia (c). Data presented are from at least three independent replicates performed in triplicate ± SEM. One-way ANOVA followed by Turkey’s multiple comparison test was used to compared within different treatment. * represents significant difference at p < 0.05, ** at p < 0.01, *** at p < 0.001