Fig. 5From: Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcomaIn vivo imaging and drug-targeting delivery of Man-NPs. a Fluorescence imaging was used to detect drug accumulation in the tumors. b Radiant efficiency in vivo at the tumor sites. c Ex vivo fluorescence imaging of tumors. d Ex vivo radiant efficiency of tumors. e Ex vivo fluorescence imaging of major organs. f The intratumoral distribution of the IR780-loaded Man-NPs with staining of CD206 (scale bar: 25 µm). Comparisons were made using the Student’s t-test; **p < 0.01Back to article page