Skip to main content
Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Role of p53/circRNA0085439/Ku70 axis in DNA damage response in lung cells exposed to ZnO nanoparticles: Involvement of epigenetic regulation

Fig. 5

Silencing p53 promoted circRNA_0085439/Ku70 complex formation post Nano-ZnO treatment. A. Flow cytometry analysis of intracellular ROS levels in p53 WT cells and p53-KO cells post 30 and 50 μg/mL of Nano-ZnO. B. Layout for the LC/MS/MS analysis of potential circRNA_0085439 binding proteins in p53 wild-type cells and p53-KO cells post 30 μg/mL of Nano-ZnO treatment. C. Expression of potential circRNA_0085439 binding DNA damage repair proteins in p53 wild-type cells and p53-KO cells post silencing circRNA_0085439 or overexpression circRNA_0085439 or post 30 μg/mL of Nano-ZnO treatment. D. RIP assay of the potential of circRNA_0085439 binding with Ku70 in p53-KO cells. E. Expression of potential circRNA_0085439 binding with Ku70 in cells treated with small interfering RNA p53 post silencing circRNA_0085439 or overexpression circRNA_0085439 or post 30 μg/mL of Nano-ZnO treatment. si-nc small interfering RNA-normal control, OE overexpression

Back to article page

Cancer Nanotechnology

ISSN: 1868-6966

Contact us