Fig. 3
A O2 generation in H2O2 solution with different concentrations of platinum–cobalt (PtCo) nanozyme with and without photodynamic therapy (PDT) and platinum–cobalt@gemcitabine-hyaluronic acid (HA)-poly[ethylene glycol] (PtCo@Gem-HA-PEG) with and without PDT. B, C The studies of catalase-like and peroxidase-like activities of with different treatments. D–F The influence of pH, temperature and physiological proteins on catalytic ability of PtCo@Gem-HA-PEG nanozyme. G, H Fluorescence spectra of hydroethidine and terephthalic acid incubated with PtCo@Gem-HA-PEG in the hypoxic condition to show the presence of O2•− and •OH, respectively. I Quantitative analyses of Gem release from PtCo@Gem-HA-PEG at 37 °C with 1 mM H2O2 and different pH. *P < 0.05, **P < 0.01, and ***P < 0.001 indicate significant differences