Fig. 3
A Hemolysis assay of the nanoparticles at various concentrations. The normal saline and water were employed as negative and positive control, respectively. B The quantification of hemolysis rate. C The plasm drug concentration–time profile upon intravenous injection of free MTO and MTO@PA/Fe3+ MOF. D The drug concentration at various tissues at 12 h after intravenous injection of free MTO and MTO@PA/Fe3+ MOF. E Dynamic monitoring of relative tumor volume after various treatments. F The photographs of mice and tumor tissues at day 12 after various treatments. G The quantification of relative tumor weight from F. H The Micro-CT images of mice after various treatments. For each group, (1) control; (2) αCTLA-4; (3) MTO@PA/Fe3+ MOF; (4) MTO@PA/Fe3+ MOF plus αCTLA-4