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Fig. 1 | Cancer Nanotechnology

Fig. 1

From: An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

Fig. 1

Synthesis of the PEI–IONPs and the apMNKQ2@PEI–IONP complexes. a TEM images of the IONPs synthesized (upper) and a histogram depicting the PEI–IONP diameter distribution calculated from the TEM images (bottom). Scale bar: 40 nm. b apMNKQ2 concentration remaining in solution after centrifugation (blue dots) and the calculated aptamer loading (brown dots). The Brown dashed line depicts the best-fit curve with a KD ~ 22.01 μM (results of an experiment performed twice in triplicate). c Z-potential (left) and hydrodynamic diameter (right) of the PEI–IONPs and apMNKQ2@PEI–IONP complexes in standard reaction buffer or in 10% mouse serum in standard reaction buffer. d Cumulative aptamer release in standard buffer over 24 h from an initial concentration of aptamer in the complex of 250 ng/μl (results of an experiment performed in triplicate)

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Cancer Nanotechnology

ISSN: 1868-6966

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