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Fig. 2 | Cancer Nanotechnology

Fig. 2

From: An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

Fig. 2

ApMNKQ2@PEI–IONP internalization and functional activity in MDA-MB-231 cells. a Mean fluorescent intensity of AlexaFluor488–apMNKQ2-labelled MDA-MB-231 cells incubated with different formulations for 24 h. b Cell viability was measured after 24 h-treatment with apMNKQ2@PEI–IONP (green) or apMNKQ2 (red) with different apMNKQ2 concentrations using the MTT assay. The viability of cells treated with the PEI–IONPs alone (at an equivalent concentration) is shown for comparison: Mann–Whitney test, one-tailed, p < 0.05, n = 3. c MNK1 expression in MDA-MB-231 cell lysates treated for 24 h with apMNKQ2 alone or complexed with PEI–IONPs at different concentrations. The graph reflects the results of three independent experiments and above a representative western blot is shown. d Phospho(Ser209)-eIF4E expression in MDA-MB-231 cell lysates treated for 24 h with apMNKQ2 alone or complexed with PEI–IONP at different concentrations. The graph reflects the results of three independent experiments and a representative western blot is shown above

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Cancer Nanotechnology

ISSN: 1868-6966

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