Fig. 1

ADAMTS9-AS1 is downregulated in ccRCC and is associated with poor prognosis. A. The expression levels of ADAMTS9-AS1 were detected by qRT-PCR in ccRCC and paired adjacent normal tissues (n = 50). B. The expression levels of ADAMTS9-AS1 were detected by qRT-PCR in ccRCC cell lines and HK-2 normal kidney cells. C. The expression levels of ADAMTS9-AS1 were detected by qRT-PCR in ccRCC of different stages (n = 50). D. Kaplan–Meier survival analysis of ccRCC patients with low or high expression of ADAMTS9-AS1 (low ADAMTS9-AS1, n = 25, high ADAMTS9-AS1, n = 25). E, F. ROC curves showing the AUROC of the combined ADAMTS9-AS1 expression and TNM stage or grade model versus AUROCs of TNM stage, grade or ADAMTS9-AS1 expression alone. The data derived from three independent experiments are presented as mean ± SEM in the bar graph (B). Controls were normalized to 1 (B). *P < 0.05, **P < 0.01