Fig. 4

ADAMTS9-AS1 inhibits tumor growth and resistance to 5-aza-dC in vivo. A–C. Tumor images (A), volumes (B), and tumor weights at the experimental endpoint (C) were compared between Lv-Flag and ADAMTS9-AS1 in A498 xenograft. Error bars, mean ± SD (n = 5 for each group). D–G Tumor images (D), volumes (E), tumor weights at the experimental endpoint (F), and body weights (G) were compared between control and shADAMTS9-AS1 in A498 xenograft with DMSO or 5-aza-dC treatment. (n = 5 for each group). H The expression levels of ADAMTS9-AS1 were detected by qRT-PCR in in A498 xenograft tissues with DMSO or 5-aza-dC treatment. The data derived from three independent experiments are presented as the mean ± SEM in the bar graph (H). Controls were normalized to 1 (H). *P < 0.05, **P < 0.01. ***P < 0.001, N.S. not significant