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Fig. 9 | Cancer Nanotechnology

Fig. 9

From: ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability

Fig. 9

Schematic diagram of ADAMTS9-AS1 regulation and function in ccRCC, ADAMTS9-AS1-HuR–ADAMTS9 axis inhibits cell growth and drug resistance. The suppression of ADAMTS9-AS1 in ccRCC is mainly due to promoter hypermethylation. 5-Aza-2′dC, an effective DNA methylation inhibitor, efficiently restores ADAMTS9-AS1 expression in ccRCC. Higher levels of ADAMTS9-AS1 inhibits tumor growth and drug resistance via recruiting HuR to enhance ADAMTS9 mRNA stability. Lower levels of ADAMTS9-AS1 cannot stabilize ADAMTS9 mRNA, resulting in cell growth and drug resistance

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Cancer Nanotechnology

ISSN: 1868-6966

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