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Table 2 Average loading efficiency and entrapment efficiency of studied formulations for DOX and Sili

From: HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer

Formulation

EE (%)

LE (%)

DOX

Sili

DOX

Sili

cGO-DOX

86.41 + 1.8

–

43.23 + 1.4

–

cGO-Sili

–

72.13 + 0.9

–

33.78 + 1.3

Apt-cGO-DOX

85.67 + 1.2

–

42.82 + 1.1

–

Apt-cGO-Sili

–

71.84 + 1.6

–

32.34 + 1.1

cGO-DOX-Sili

84.78 + 2.1

71.12 + 1.4

41.68 + 1.2

31.98 + 0.9

Apt-cGO-DOX-Sili

84.22 + 1.8

70.42 + 1.2

41.4 + 1.8

30.3 + 0.7

  1. LE: loading efficiency; EE: entrapment efficiency; cGO: carboxylated graphene oxide; Apt: aptamer; DOX: doxorubicin; Sili: silibinin