Skip to main content

Table 3 IC50 values of studied formulations toward MCF-7 and SK-BR-3 after 48 h

From: HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer

 

IC50 values (log of [µg/mL])

p-value

SK-BR-3

MCF-7

Free Sili

1.42 + 0.09

1.581 + 0.1

0.021

cGO-Sili

1.097 + 0.09

1.252 + 0.2

0.792

Apt-cGO-Sili

0.963 + 0.05

1.108 + 0.1

0.14

Free DOX

− 0.712 + 0.06

− 0.761 + 0.1

0.961

cGO-DOX

− 1.163 + 0.09

− 0.899 + 0.01

0.004

Apt-cGO-DOX

− 1.239 + 0.05

− 0.999 + 0.02

0.005

Apt-cGO-DOX-Sili

− 1.329 + 0.08

− 0.613 + 0.01

< 0.0001