Table 1 Mφ-derived EVs in tumors
From: Emerging applications of extracellular vesicles in tumor therapy
Source | Therapeutic agent | Targeting tumors/cells | Research models | Tumor cell lines | Outcomes | References |
|---|---|---|---|---|---|---|
ImDCs | DOX | Breast cancer | In vivo/in vitro | MDA-MB-231 and MCF-7 | Increased targeting and delivery of chemotherapeutic agents | Tian et al. (2014) |
M1φ | PTX | Breast cancer | In vivo/in vitro | 4T1 | Increased anti-tumor activity of the drug | Wang et al. (2019) |
M1φ | GEM and DFX | Pancreatic cancer | In vivo/in vitro | PANC-1 | Inhibited cancer cell proliferation, cell attachment and migration, and chemoresistance to GEM significantly improved therapeutic efficacy | Zhao et al. (2021) |
M1φ | CPPO, Ce6 and AQ4N | Glioblastoma multiforme | In vivo/in vitro | U87MG-luc, GL261-luc, and G422-luc | Achieved a strong therapeutic effect with synergistic immunomodulation, CDT and hypoxia-activated chemotherapy | Wang et al. (2022) |
RAW 264.7 cell | HA, CV and DOX | Breast Cancer | In vivo/in vitro | 4T1 | Reduced macrophage polarization regulation and cell migration enhance the therapeutic effect on metastatic cancer | Jorquera-Cordero et al. (2022) |
RAW 264.7 cell | PTX | Lewis lung carcinoma | In vivo/in vitro | 3LL-M27 | Increased toxicity to cancer cells and localization to tumors | Kim et al. (2016) |
RAW 264.7 cell | AA-PEG and PTX | Lewis lung carcinoma | In vivo/in vitro | 3LL-M27 | Increased toxicity to cancer cells and localization to tumors | Kim et al. (2018) |
M1φ | lactic acid-ethanolic acid and DOX | TNBC | In vivo/in vitro | MDA-MB-231 | Increased cellular uptake efficiency and antitumor efficacy of adriamycin, leading to increased tumor growth inhibition and induction of apoptosis | Li et al. (2020) |
RAW 264.7 cell | DOX | Breast cancer | In vitro | 4T1 | Enhanced toxicity to cancer cells | Fu et al. (2015) |
RAW 264.7 cell | – | Mouse cortical neurons, microglia and astrocytes | In vivo/in vitro | CCL-131 | Downregulated pro-inflammatory miRNA target genes in receptor cells to prophylactically reduce chronic pain | |
M1φ | – | Melanoma | In vivo/in vitro | B16F10 | Increased pro-inflammatory cytokine ratios induced stronger and more sustained immune responses, and exhibited stronger anti-tumor effects | Cheng et al. (2017) |