Table 4 Vincristine predicted toxicity profile by interaction with different systems of the body
Parameters | Predicted values | Explanation |
|---|---|---|
Mutagenic potential | Negative | Â |
Chromosomal aberration | Toxic (60%) | Predicts whether or not the compound will trigger the mutagenic chromosomal aberrations Overall accuracy = 80% |
hERG pIC50 | 4.62663374 | Affinity to the hERG potassium channel in human expressed as pIC_50 in mol/L. RMSE/MAE = 0.55/0.43 in log units (2D and 3D) |
p-Lipidosis | Negative | Qualitative estimation of causing phospholipidosis. Overall accuracy = 96% |
Liver toxicity ALT | Yes Elevated 94% | Predicts whether or not the compound will cause elevation in the levels of SGPT enzyme Overall accuracy = 89% |
AST | Elevated 46% | Predicts whether or not the compound will cause elevation in the levels of SGOT enzyme Overall accuracy = 84% |
ALP | Elevated 48% | Predicts whether or not the compound will cause elevation in the levels of Alkaline Phosphatase enzyme. Overall accuracy = 91% |
Serum GGT | Normal | Predicts whether or not the compound will cause elevation in the levels of GGT enzyme Overall accuracy = 94% |
Serum LDH | Elevated 45% | Predicts whether or not the compound will cause elevation in the levels of LDH enzyme Overall accuracy = 95% |
Reproductive toxicity | Yes (81%) | Qualitative estimation of reproductive/developmental toxicity. Overall accuracy = 90% |
Rat TD50 | 0.271373 | TD50 for rat carcinogenicity (mg/kg/day in oral dose) over a standard lifetime. RMSE/MAE = 0.54/0.42 (2D) and 0.52/0.43 (3D) in log units |