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Table 2 Complete blood profile with renal and hepatic parameters in control, CC, pure NDV and HA-TC-NDV groups

From: Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts

Parameters

Control (n = 10)

Cervical cancer (n = 10)

Pure NDV (n = 10)

HA-TC-NDV (n = 10)

Range (unit)

RBC profile

 

 RBC count

5.8 ± 0.41

3.39 ± 0.20

2.96 ± 0.32

4.9 ± 0.24

4–5.9 × 1012/L

 Hemoglobin

15 ± 0.27

7.1 ± 0.15

7.5 ± 0.25

9.1 ± 0.71

12–16 × g/dL

 Hematocrit

45.98 ± 1.20

30.72 ± 2.1

30.93 ± 2.0

33 ± 1.63

35–50%

 MCV

47 ± 0.61

98.7 ± 0.39

87.64 ± 0.73

72.5 ± 0.41

40–60 fl

 MCH

25 ± 0.51

18.5 ± 0.35

15.3 ± 0.6

20.3 ± 0.38

21–31 pg

 MCHC

30 ± 0.47

48.4 ± 0.56

45.72 ± 0.45

42.3 ± 0.51

30–39%

 Hemolysis

2 ± 0

10.67 ± 0.3

24 ± 0.3

16.2 ± 0.4

0%

 RBC morphology

Normal

Macrocytic

Normal

Normal

Normal

WBC profile

 

 WBC count

7.4 ± 1.31

32.1 ± 2.5

9.0 ± 1.51

10.2 ± 0.51

4.5–11.0 × 103/µL

 Neutrophils

22 ± 1.86

16 ± 1.4

20 ± 1.33

23 ± 3.12

21–57%

 Lymphocytes

50 ± 3.0

94 ± 3.1

70 ± 3.61

59 ± 2.52

49–82%

 Monocytes

1.63 ± 0.51

9.7 ± 0.2

2.9 ± 0.51

2.68 ± 0.4

1.7–4.3%

 Eosinophils

2.31 ± 0.22

15 ± 0.17

3.9 ± 0.16

1.94 ± 0.64

0–3%

 Basophils

2.30 ± 0.17

0.22 ± 0.32

0.7 ± 0.31

2.14 ± 0.31

0–3%

 WBC morphology

Normal

Abnormal

Abnormal

Abnormal

Normal

Platelet profile

 Count

380,000 ± 0.39

470,000 ± 0.47

320,000 ± 0.43

355,000 ± 0.36

150,000–450,000 μL

 Morphology

Normal

Normal

Normal

Normal

Normal

Kidney function test

 BUN

16.23 ± 0.13

30 ± 0.44

26 ± 1.05

19 ± 0.29

18–29 mg/dL

 Creatinine

0.1 ± 0.02

0.35 ± 0.18

0.5 ± 0.19

0.35 ± 0.11

0.1–0.4 mg/dL

Liver function test

 ALT

19 ± 4.1

50 ± 3.15

25 ± 4.12

27 ± 4.72

4.1–36 U/L

 AST

13 ± 2.12

45 ± 3.4

30 ± 3.54

25.66 ± 4.17

8.1–33 U/L

 ALP

15 ± 1.67

47.1 ± 3.1

31 ± 2.27

36.33 ± 4.6

4.1–40 U/L