Fig. 3

MB49 bladder tumor accumulation of CP-GNPs. Intra-tumoral accumulation of increasing doses of CP-GNP was measured in MB49-tumor bearing mice using ICP-OES. A 20 mg/kg and 50 mg/kg CP-GNP showed significantly higher intra-tumoral accumulation than the lower 13 mg/kg dose on day 14 after administration. *p<0.05 for 20 mg/kg and 50 mg/kg vs. 13 mg/kg; #p<0.05 for 50 mg/kg vs. 20 mg/kg; Student's t-test. B Intra-tumoral accumulation of 20 mg/kg CP-GNP was significantly higher than that of 20 mg/kg free CP, on day 4 after administration. *p<0.05, Student's t-test. C Intra-tumoral accumulation of 20 mg/kg CP-GNP 4 day post-administration was significantly higher than that on day 14 post-administration. *p<0.05, Student's t-test