Fig. 4

Effect of single high-dose CP or CP-GNP injection on MB49 tumor-bearing mice. A Tumor growth was inhibited in free CP-treated and CP-GNP-treated mice as compared to untreated mice. Tumor growth normalized to initial volume. *p < 0.05 vs. untreated, Student’s t test. B Kaplan–Meier survival curve. Early mortality occurred in CP-treated mice as compared to prolonged survival of CP-GNP treated mice. C Weight level in CP-treated mice was significantly reduced as compared to untreated; weight in CP-GNP-treated mice remained steady except for a decrease on day 14 (p < 0.05 for *free CP-treated and ^#CP-GNP treated vs. untreated; Student’s t-test. Weight and tumor growth results presented as mean ± SEM